UniProt Accession

 RB33B_HUMAN; Q9H082; B2R987; Q4W5B0 

Genbank Protein ID

 AF350420; AL136904; AK313685; AC114743; BC111977 

Genbank Nucleotide ID

 AAL83916.1; CAB66838.1; BAG36434.1; AAY40936.1; AAI11978.1 

Protein Name

 Ras-related protein Rab-33B 

Protein Synonyms/Alias

  

Gene Name

 RAB33B 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
149	PRILVGNKCDLRSAI	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 

Functional Description

 Protein transport. Acts, in coordination with RAB6A, to regulate intra-Golgi retrograde trafficking. It is involved in autophagy, acting as a modulator of autophagosome formation. 

Sequence Annotation

 NP_BIND 39 46 GTP (By similarity).
 NP_BIND 88 92 GTP (By similarity).
 NP_BIND 148 151 GTP (By similarity).
 MOD_RES 229 229 Cysteine methyl ester (By similarity).
 LIPID 227 227 S-geranylgeranyl cysteine (By
 LIPID 229 229 S-geranylgeranyl cysteine (By  

Keyword

 Autophagy; Complete proteome; Disease mutation; Dwarfism; Golgi apparatus; GTP-binding; Lipoprotein; Membrane; Methylation; Nucleotide-binding; Prenylation; Protein transport; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 229 AA 

Protein Sequence

Gene Ontology

 GO:0005796; C:Golgi lumen; IDA:UniProtKB.
 GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0006914; P:autophagy; IEA:UniProtKB-KW.
 GO:0015031; P:protein transport; IEA:UniProtKB-KW.
 GO:2000785; P:regulation of autophagic vacuole assembly; ISS:UniProtKB.
 GO:2000156; P:regulation of retrograde vesicle-mediated transport, Golgi to ER; IMP:UniProtKB.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR003579; Small_GTPase_Rab_type. 

Pfam

 PF00071; Ras 

SMART

 SM00175; RAB 

PROSITE

 PS51419; RAB 

PRINTS

 PR00449; RASTRNSFRMNG.