CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030522
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Endoribonuclease Dicer 
Protein Synonyms/Alias
 cDNA FLJ34194 fis, clone FCBBF3018591, highly similar to Endoribonuclease Dicer (EC 3.1.26.-) 
Gene Name
 DICER1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
248LSYMRSKKVSNCNLYubiquitination[1]
363MGSGAFVKKISLSPFubiquitination[2]
364GSGAFVKKISLSPFSubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 820 AA 
Protein Sequence
MLAWESDHFL RILAENDNYC KHSTIVPENA AHQGANRTSS LENHDQMSVN CRTLLSESPG 60
KLHVEVSADL TAINGLSYNQ NLANGSYDLA NRDFCQGNQL NYYKQEIPVQ PTTSYSIQNL 120
YSYENQPQPS DECTLLSNKY LDGNANKSTS DGSPVMAVMP GTTDTIQVLK GRMDSEQSPS 180
IGYSSRTLGP NPGLILQALT LSNASDGFNL ERLEMLGDSF LKHAITTYLF CTYPDAHEGR 240
LSYMRSKKVS NCNLYRLGKK KGLPSRMVVS IFDPPVNWLP PGYVVNQDKS NTDKWEKDEM 300
TKDCMLANGK LDEDYEEEDE EEESLMWRAP KEEADYEDDF LEYDQEHIRF IDNMLMGSGA 360
FVKKISLSPF STTDSAYEWK MPKKSSLGSM PFSSDFEDFD YSSWDAMCYL DPSKAVEEDD 420
FVVGFWNPSE ENCGVDTGKQ SISYDLHTEQ CIADKSIADC VEALLGCYLT SCGERAAQLF 480
LCSLGLKVLP VIKRTDREKA LCPTRENFNS QQKNLSVSCA AASVASSRSS VLKDSEYGCL 540
KIPPRCMFDH PDADKTLNHL ISGFENFEKK INYRFKNKAY LLQAFTHASY HYNTITDCYQ 600
RLEFLGDAIL DYLITKHLYE DPRQHSPGVL TDLRSALVNN TIFASLAVKY DYHKYFKAVS 660
PELFHVIDDF VQFQLEKNEM QGMDSELRRS EEDEEKEEDI EVPKAMGDIF ESLAGAIYMD 720
SGMSLETVWQ VYYPMMRPLI EKFSANVPRS PVRELLEMEP ETAKFSPAER TYDGKVRVTV 780
EVVGKGKFKG VGRSYRIAKS AAARRALRSL KANQPQVPNS 820 
Gene Ontology
 GO:0003725; F:double-stranded RNA binding; IEA:InterPro.
 GO:0004525; F:ribonuclease III activity; IEA:InterPro.
 GO:0006396; P:RNA processing; IEA:InterPro. 
Interpro
 IPR001159; Ds-RNA-bd.
 IPR014720; dsRNA-bd-like_dom.
 IPR000999; RNase_III_dom. 
Pfam
 PF00636; Ribonuclease_3 
SMART
 SM00358; DSRM
 SM00535; RIBOc 
PROSITE
 PS50137; DS_RBD
 PS00517; RNASE_3_1
 PS50142; RNASE_3_2 
PRINTS