UniProt Accession

 B0UXQ0_HUMAN; B0UXQ0 

Genbank Protein ID

 CR382333; HM595424; AM944568 

Genbank Nucleotide ID

 ADQ48108.1; CAQ16345.1 

Protein Name

 HLA class I histocompatibility antigen, A-68 alpha chain 

Protein Synonyms/Alias

 MHC class I antigen 

Gene Name

 HLA-A 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
145	RQDAYDGKDYIALNE	ubiquitination	[1]
340	RRKSSDRKGGSYSQA	ubiquitination	[1, 2]
364	DMSLTACKV******	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

 Involved in the presentation of foreign antigens to the immune system (By similarity). 

Sequence Annotation

  

Keyword

 Complete proteome; Disulfide bond; Immunity; Membrane; MHC I; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 365 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0042612; C:MHC class I protein complex; IEA:UniProtKB-KW.
 GO:0002474; P:antigen processing and presentation of peptide antigen via MHC class I; IEA:UniProtKB-KW.
 GO:0006955; P:immune response; IEA:InterPro. 

Interpro

 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003006; Ig/MHC_CS.
 IPR003597; Ig_C1-set.
 IPR011161; MHC_I-like_Ag-recog.
 IPR011162; MHC_I/II-like_Ag-recog.
 IPR001039; MHC_I_a_a1/a2.
 IPR010579; MHC_I_a_C. 

Pfam

 PF07654; C1-set
 PF00129; MHC_I
 PF06623; MHC_I_C 

SMART

 SM00407; IGc1 

PROSITE

 PS50835; IG_LIKE
 PS00290; IG_MHC 

PRINTS

 PR01638; MHCCLASSI.