CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016960
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Armadillo repeat-containing protein 8 
Protein Synonyms/Alias
  
Gene Name
 ARMC8 
Gene Synonyms/Alias
 S863-2 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
248VKMLQRDKPIEMQLTubiquitination[1]
279DDNCIVLKTLPCLVRubiquitination[1]
399GLSESSVKVRLAAVRubiquitination[1]
429FQDHAVWKPLMKVLQubiquitination[1]
665SNLCDKAKMALQQYLubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
  
Sequence Annotation
 REPEAT 51 92 ARM 1.
 REPEAT 95 134 ARM 2.
 REPEAT 138 176 ARM 3.
 REPEAT 178 217 ARM 4.
 REPEAT 224 265 ARM 5.
 REPEAT 269 309 ARM 6.
 REPEAT 313 352 ARM 7.
 REPEAT 374 413 ARM 8.
 REPEAT 416 455 ARM 9.
 REPEAT 458 497 ARM 10.
 REPEAT 501 540 ARM 11.
 REPEAT 543 585 ARM 12.
 REPEAT 588 627 ARM 13.
 REPEAT 634 673 ARM 14.
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 391 391 Phosphothreonine (By similarity).  
Keyword
 Acetylation; Alternative splicing; Complete proteome; Direct protein sequencing; Phosphoprotein; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 673 AA 
Protein Sequence
MACLLETPIR MSVLSEVTAS SRHYVDRLFD PDPQKVLQGV IDMKNAVIGN NKQKANLIVL 60
GAVPRLLYLL QQETSSTELK TECAVVLGSL AMGTENNVKS LLDCHIIPAL LQGLLSPDLK 120
FIEACLRCLR TIFTSPVTPE ELLYTDATVI PHLMALLSRS RYTQEYICQI FSHCCKGPDH 180
QTILFNHGAV QNIAHLLTSL SYKVRMQALK CFSVLAFENP QVSMTLVNVL VDGELLPQIF 240
VKMLQRDKPI EMQLTSAKCL TYMCRAGAIR TDDNCIVLKT LPCLVRMCSK ERLLEERVEG 300
AETLAYLIEP DVELQRIASI TDHLIAMLAD YFKYPSSVSA ITDIKRLDHD LKHAHELRQA 360
AFKLYASLGA NDEDIRKKII ETENMMDRIV TGLSESSVKV RLAAVRCLHS LSRSVQQLRT 420
SFQDHAVWKP LMKVLQNAPD EILVVASSML CNLLLEFSPS KEPILESGAV ELLCGLTQSE 480
NPALRVNGIW ALMNMAFQAE QKIKADILRS LSTEQLFRLL SDSDLNVLMK TLGLLRNLLS 540
TRPHIDKIMS THGKQIMQAV TLILEGEHNI EVKEQTLCIL ANIADGTTAK DLIMTNDDIL 600
QKIKYYMGHS HVKLQLAAMF CISNLIWNEE EGSQERQDKL RDMGIVDILH KLSQSPDSNL 660
CDKAKMALQQ YLA 673 
Gene Ontology
  
Interpro
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR000225; Armadillo. 
Pfam
 PF00514; Arm 
SMART
 SM00185; ARM 
PROSITE
 PS50176; ARM_REPEAT
 PS50077; HEAT_REPEAT 
PRINTS