CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010272
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Probable 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD 
Protein Synonyms/Alias
  
Gene Name
 arnD 
Gene Synonyms/Alias
 pmrJ; yfbH; b2256; JW2250 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
60VKPQFLWKMLRSNAAacetylation[1]
209EVIGRDVKAEDFNGWacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 
Functional Description
 Catalyzes the deformylation of 4-deoxy-4-formamido-L- arabinose-phosphoundecaprenol to 4-amino-4-deoxy-L-arabinose- phosphoundecaprenol. The modified arabinose is attached to lipid A and is required for resistance to polymyxin and cationic antimicrobial peptides (Probable). 
Sequence Annotation
  
Keyword
 Antibiotic resistance; Complete proteome; Hydrolase; Lipid A biosynthesis; Lipid biosynthesis; Lipid metabolism; Lipopolysaccharide biosynthesis; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 296 AA 
Protein Sequence
MTKVGLRIDV DTFRGTREGV PRLLEILSKH NIQASIFFSV GPDNMGRHLW RLVKPQFLWK 60
MLRSNAASLY GWDILLAGTA WPGKEIGHAN ADIIREAAKH HEVGLHAWDH HAWQARSGNW 120
DRQTMIDDIA RGLRTLEEII GQPVTCSAAA GWRADQKVIE AKEAFHLRYN SDCRGAMPFR 180
PLLESGNPGT AQIPVTLPTW DEVIGRDVKA EDFNGWLLNR ILRDKGTPVY TIHAEVEGCA 240
YQHNFVDLLK RAAQEGVTFC PLSELLSETL PLGQVVRGNI AGREGWLGCQ QIAGSR 296 
Gene Ontology
 GO:0016811; F:hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides; IEA:HAMAP.
 GO:0036108; P:4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0009245; P:lipid A biosynthetic process; IEA:HAMAP.
 GO:0009103; P:lipopolysaccharide biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
 GO:0010041; P:response to iron(III) ion; IGI:EcoCyc. 
Interpro
 IPR023557; ArnD.
 IPR011330; Glyco_hydro/deAcase_b/a-brl.
 IPR002509; Polysac_deacetylase. 
Pfam
 PF01522; Polysacc_deac_1 
SMART
  
PROSITE
  
PRINTS