UniProt Accession

 ABCF2_HUMAN; Q9UG63; O60864; Q75MJ0; Q96TE8 

Genbank Protein ID

 AF261091; AF261092; BT007451; AL050291; AC021097; CH471173; CH471173; BC001661; AJ005016 

Genbank Nucleotide ID

 AAG13902.1; AAG13903.1; AAP36119.1; CAB43392.1; AAS00379.1; EAW54014.1; EAW54017.1; AAH01661.1; CAA06290.1 

Protein Name

 ATP-binding cassette sub-family F member 2 

Protein Synonyms/Alias

 Iron-inhibited ABC transporter 2 

Gene Name

 ABCF2 

Gene Synonyms/Alias

 HUSSY-18 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
66	ELEDFEMKKAAARAV	ubiquitination	[1]
133	MLLSAIGKREVPIPE	ubiquitination	[2]
174	TERAMLEKEAERLAH	ubiquitination	[1, 2]
188	HEDAECEKLMELYER	ubiquitination	[2]
203	LEELDADKAEMRASR	ubiquitination	[1, 2]
227	AMQRKKLKDFSGGWR	ubiquitination	[2]
304	HMHNKKLKYYTGNYD	acetylation	[3]
315	GNYDQYVKTRLELEE	ubiquitination	[1, 2, 4, 5]
326	ELEENQMKRFHWEQD	ubiquitination	[1, 2]
339	QDQIAHMKNYIARFG	ubiquitination	[2, 4]
351	RFGHGSAKLARQAQS	ubiquitination	[2]
365	SKEKTLQKMMASGLT	ubiquitination	[1, 2, 4, 5]
436	VGPNGAGKSTLLKLL	ubiquitination	[2, 4]
441	AGKSTLLKLLTGELL	ubiquitination	[2]
508	GRYGLTGKQQVSPIR	ubiquitination	[1, 2, 5]
522	RNLSDGQKCRVCLAW	ubiquitination	[1, 6]
588	QEIWVCEKQTITKWP	ubiquitination	[2, 6]
602	PGDILAYKEHLKSKL	ubiquitination	[1, 2, 4]
606	LAYKEHLKSKLVDEE	ubiquitination	[2]
608	YKEHLKSKLVDEEPQ	ubiquitination	[1, 2]
618	DEEPQLTKRTHNV**	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [5] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [6] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931] 

Functional Description

  

Sequence Annotation

 DOMAIN 86 325 ABC transporter 1.
 DOMAIN 396 613 ABC transporter 2.
 NP_BIND 118 125 ATP 1 (By similarity).
 NP_BIND 430 437 ATP 2 (By similarity).
 MOD_RES 304 304 N6-acetyllysine.  

Keyword

 Acetylation; ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 623 AA 

Protein Sequence

Gene Ontology

 GO:0043190; C:ATP-binding cassette (ABC) transporter complex; TAS:ProtInc.
 GO:0005740; C:mitochondrial envelope; TAS:ProtInc.
 GO:0005524; F:ATP binding; TAS:ProtInc.
 GO:0016887; F:ATPase activity; IEA:InterPro.
 GO:0005215; F:transporter activity; TAS:ProtInc.
 GO:0006200; P:ATP catabolic process; IEA:GOC. 

Interpro

 IPR003593; AAA+_ATPase.
 IPR003439; ABC_transporter-like.
 IPR017871; ABC_transporter_CS.
 IPR027417; P-loop_NTPase. 

Pfam

 PF00005; ABC_tran 

SMART

 SM00382; AAA 

PROSITE

 PS00211; ABC_TRANSPORTER_1
 PS50893; ABC_TRANSPORTER_2 

PRINTS