| Tag | Content |
|---|
| CPLM ID | CPLM-019626 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Ran-binding protein 9 |
Protein Synonyms/Alias | RanBP9; BPM-L; BPM90; Ran-binding protein M; RanBPM; RanBP7 |
Gene Name | RANBP9 |
Gene Synonyms/Alias | RANBPM |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 64 | LEELASIKNRQRIQK | ubiquitination | [1] | | 104 | PNLLFTLKVRQFIEM | ubiquitination | [1] | | 304 | CGKNTANKKMLKDAF | ubiquitination | [1] | | 308 | TANKKMLKDAFSLLA | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | May act as an adapter protein to couple membrane receptors to intracellular signaling pathways. May be involved in signaling of ITGB2/LFA-1 and other integrins. Enhances HGF-MET signaling by recruiting Sos and activating the Ras pathway. Enhances dihydrotestosterone-induced transactivation activity of AR, as well as dexamethasone-induced transactivation activity of NR3C1, but not affect estrogen-induced transactivation. Stabilizes TP73 isoform Alpha, probably by inhibiting its ubiquitination, and increases its proapoptotic activity. Inhibits the kinase activity of DYRK1A and DYRK1B. Inhibits FMR1 binding to RNA (By similarity). |
Sequence Annotation | DOMAIN 147 334 B30.2/SPRY.
DOMAIN 365 397 LisH.
DOMAIN 403 460 CTLH.
REGION 401 407 Interaction with CALB1 (Probable).
REGION 615 729 Interaction with FMR1.
MOD_RES 405 405 N6-acetyllysine.
MOD_RES 487 487 Phosphoserine. |
Keyword | Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Nucleus; Phosphoprotein; Reference proteome; Ubl conjugation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 729 AA |
Protein Sequence | MREWRTKIQA QIDRFPIGDR EGEWQTMIQK MVSSYLVHHG YCATAEAFAR STDQTVLEEL 60
ASIKNRQRIQ KLVLAGRMGE AIETTQQLYP SLLERNPNLL FTLKVRQFIE MVNGTDSEVR 120
CLGGRSPKSQ DSYPVSPRPF SSPSMSPSHG MNIHNLASGK GSTAHFSGFE SCSNGVISNK 180
AHQSYCHSNK HQSSNLNVPE LNSINMSRSQ QVNNFTSNDV DMETDHYSNG VGETSSNGFL 240
NGSSKHDHEM EDCDTEMEVD SSQLRRQLCG GSQAAIERMI HFGRELQAMS EQLRRDCGKN 300
TANKKMLKDA FSLLAYSDPW NSPVGNQLDP IQREPVCSAL NSAILETHNL PKQPPLALAM 360
GQATQCLGLM ARSGIGSCAF ATVEDYLH 388 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |