UniProt Accession

 E7EMR6_HUMAN; E7EMR6 

Genbank Protein ID

 AC007421; AC087388 

Genbank Nucleotide ID

  

Protein Name

 Cellular tumor antigen p53 

Protein Synonyms/Alias

  

Gene Name

 TP53 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
101	SSSVPSQKTYQGSYG	ubiquitination	[1]
120	FLHSGTAKSVTCTYS	ubiquitination	[2, 3, 4]
132	TYSPALNKMFCQLAK	ubiquitination	[1, 3]
139	KMFCQLAKTCPVQLW	ubiquitination	[3]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931] 

Functional Description

 Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression (By similarity). 

Sequence Annotation

  

Keyword

 Activator; Apoptosis; Cell cycle; Complete proteome; Cytoplasm; DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Transcription; Transcription regulation; Tumor suppressor; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 165 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IEA:Compara.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0005657; C:replication fork; IEA:Compara.
 GO:0003682; F:chromatin binding; IEA:Compara.
 GO:0035033; F:histone deacetylase regulator activity; IEA:Compara.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0001077; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; IEA:Compara.
 GO:0044212; F:transcription regulatory region DNA binding; IEA:InterPro.
 GO:0002326; P:B cell lineage commitment; IEA:Compara.
 GO:0007569; P:cell aging; IEA:Compara.
 GO:0071479; P:cellular response to ionizing radiation; IEA:Compara.
 GO:0034644; P:cellular response to UV; IEA:Compara.
 GO:0007417; P:central nervous system development; IEA:Compara.
 GO:0051276; P:chromosome organization; IEA:Compara.
 GO:0008340; P:determination of adult lifespan; IEA:Compara.
 GO:0006977; P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest; IEA:Compara.
 GO:0006302; P:double-strand break repair; IEA:Compara.
 GO:0007369; P:gastrulation; IEA:Compara.
 GO:0001701; P:in utero embryonic development; IEA:Compara.
 GO:0006917; P:induction of apoptosis; IEA:Compara.
 GO:0042771; P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; IEA:Compara.
 GO:0071850; P:mitotic cell cycle arrest; IEA:Compara.
 GO:0035264; P:multicellular organism growth; IEA:Compara.
 GO:0043066; P:negative regulation of apoptotic process; IEA:Compara.
 GO:0008156; P:negative regulation of DNA replication; IEA:Compara.
 GO:0048147; P:negative regulation of fibroblast proliferation; IEA:Compara.
 GO:0007406; P:negative regulation of neuroblast proliferation; IEA:Compara.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IEA:Compara.
 GO:0030512; P:negative regulation of transforming growth factor beta receptor signaling pathway; IEA:Compara.
 GO:0051402; P:neuron apoptotic process; IEA:Compara.
 GO:0090343; P:positive regulation of cell aging; IEA:Compara.
 GO:0031065; P:positive regulation of histone deacetylation; IEA:Compara.
 GO:0043525; P:positive regulation of neuron apoptotic process; IEA:Compara.
 GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IEA:Compara.
 GO:0070245; P:positive regulation of thymocyte apoptotic process; IEA:Compara.
 GO:0000060; P:protein import into nucleus, translocation; IEA:Compara.
 GO:0046902; P:regulation of mitochondrial membrane permeability; IEA:Compara.
 GO:0001836; P:release of cytochrome c from mitochondria; IEA:Compara.
 GO:0042493; P:response to drug; IEA:Compara.
 GO:0010332; P:response to gamma radiation; IEA:Compara.
 GO:0006979; P:response to oxidative stress; IEA:Compara.
 GO:0009651; P:response to salt stress; IEA:Compara.
 GO:0010165; P:response to X-ray; IEA:Compara.
 GO:0009303; P:rRNA transcription; IEA:Compara.
 GO:0001756; P:somitogenesis; IEA:Compara.
 GO:0033077; P:T cell differentiation in thymus; IEA:Compara.
 GO:0002360; P:T cell lineage commitment; IEA:Compara.
 GO:0002309; P:T cell proliferation involved in immune response; IEA:Compara.
 GO:0007179; P:transforming growth factor beta receptor signaling pathway; IEA:Compara. 

Interpro

 IPR008967; p53-like_TF_DNA-bd.
 IPR012346; p53/RUNT-type_TF_DNA-bd.
 IPR011615; p53_DNA-bd.
 IPR013872; p53_transactivation_domain.
 IPR002117; p53_tumour_suppressor. 

Pfam

 PF00870; P53
 PF08563; P53_TAD 

SMART

  

PROSITE

  

PRINTS

 PR00386; P53SUPPRESSR.