UniProt Accession

 M1_I34A1; P03485; A4GXH8; Q20N36; Q77HF4 

Genbank Protein ID

 V01099; AF389121; EF467824; CY009445 

Genbank Nucleotide ID

 CAA24282.1; AAM75161.1; ABO21712.1; ABD77676.1 

Protein Name

 Matrix protein 1 

Protein Synonyms/Alias

 M1 

Gene Name

 M 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Influenza A virus (strain A/Puerto Rico/8/1934 H1N1) 

NCBI Taxa ID

 211044 

Lysine Modification

Position	Peptide	Type	References
242	ENLQAYQKRMGVQMQ	sumoylation	[1]

Reference

 [1] The SUMOylation of matrix protein M1 modulates the assembly and morphogenesis of influenza A virus.
 Wu CY, Jeng KS, Lai MM.
 J Virol. 2011 Jul;85(13):6618-28. [PMID: 21507966] 

Functional Description

 Plays critical roles in virus replication, from virus entry and uncoating to assembly and budding of the virus particle. M1 binding to ribonucleocapsids (RNPs) in nucleus seems to inhibit viral transcription. Interaction of viral NEP with M1-RNP is thought to promote nuclear export of the complex, which is targeted to the virion assembly site at the apical plasma membrane in polarized epithelial cells. Interactions with NA and HA may bring M1, a non-raft-associated protein, into lipid rafts. Forms a continuous shell on the inner side of the lipid bilayer in virion, where it binds the RNP. During virus entry into cell, the M2 ion channel acidifies the internal virion core, inducing M1 dissociation from the RNP. M1-free RNPs are transported to the nucleus, where viral transcription and replication can take place. 

Sequence Annotation

 REGION 1 164 Membrane-binding.
 REGION 165 252 RNP-binding.
 MOTIF 101 105 Nuclear localization signal.  

Keyword

 3D-structure; Alternative splicing; Complete proteome; Host nucleus; Host-virus interaction; Inhibition of host complement factors by virus; Membrane; Reference proteome; RNA-binding; Viral immunoevasion; Viral matrix protein; Virion. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 252 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:Reactome.
 GO:0030666; C:endocytic vesicle membrane; TAS:Reactome.
 GO:0031904; C:endosome lumen; TAS:Reactome.
 GO:0005576; C:extracellular region; TAS:Reactome.
 GO:0042025; C:host cell nucleus; IEA:UniProtKB-SubCell.
 GO:0005654; C:nucleoplasm; TAS:Reactome.
 GO:0005886; C:plasma membrane; TAS:Reactome.
 GO:0055036; C:virion membrane; IEA:UniProtKB-SubCell.
 GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
 GO:0005198; F:structural molecule activity; IEA:InterPro.
 GO:0075733; P:intracellular transport of viral material; TAS:Reactome.
 GO:0039573; P:suppression by virus of host complement activation; IEA:UniProtKB-KW.
 GO:0019061; P:uncoating of virus; TAS:Reactome.
 GO:0019064; P:viral entry into host cell via membrane fusion with the plasma membrane; TAS:Reactome.
 GO:0019065; P:viral entry into host cell via receptor-mediated endocytosis; TAS:Reactome.
 GO:0019070; P:viral genome maturation; TAS:Reactome.
 GO:0019072; P:viral genome packaging; TAS:Reactome.
 GO:0019076; P:viral release from host cell; TAS:Reactome.
 GO:0019083; P:viral transcription; TAS:Reactome. 

Interpro

 IPR013188; Flu_matrix_M1_C.
 IPR001561; Flu_matrix_M1_N.
 IPR015423; Flu_matrix_M1_N_sub1.
 IPR015799; Flu_matrix_M1_N_sub2. 

Pfam

 PF00598; Flu_M1
 PF08289; Flu_M1_C 

SMART

 SM00759; Flu_M1_C 

PROSITE

  

PRINTS