| Tag | Content |
|---|
| CPLM ID | CPLM-010929 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Chromatin structure-remodeling complex subunit RSC4 |
Protein Synonyms/Alias | RSC complex subunit RSC4; Remodel the structure of chromatin complex subunit 4 |
Gene Name | RSC4 |
Gene Synonyms/Alias | YKR008W; YK107 |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 25 | RPKYLPGKHPKNQEK | acetylation | [1, 2] | | 410 | STTSDIEKTNSLESE | acetylation | [2] | | 423 | SEHLKIPKYNVIKSM | acetylation | [2] | | 468 | NLYSQATKPLLGSRP | acetylation | [2] |
|
Reference | [1] Autoregulation of the rsc4 tandem bromodomain by gcn5 acetylation. VanDemark AP, Kasten MM, Ferris E, Heroux A, Hill CP, Cairns BR. Mol Cell. 2007 Sep 7;27(5):817-28. [ PMID: 17803945] [2] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae. Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C. Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [ PMID: 22865919] |
Functional Description | Component of the chromatin structure remodeling complex (RSC), which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton. |
Sequence Annotation | DOMAIN 72 141 Bromo 1.
DOMAIN 205 275 Bromo 2.
MOD_RES 199 199 Phosphoserine.
MOD_RES 545 545 Phosphoserine. |
Keyword | 3D-structure; Bromodomain; Chromatin regulator; Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Repeat; Transcription; Transcription regulation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 625 AA |
Protein Sequence | MVVKKRKLAT EAGGSDERPK YLPGKHPKNQ EKTPHVDYNA PLNPKSELFL DDWHIPKFNR 60
FISFTLDVLI DKYKDIFKDF IKLPSRKFHP QYYYKIQQPM SINEIKSRDY EYEDGPSNFL 120
LDVELLTKNC QAYNEYDSLI VKNSMQVVML IEFEVLKAKN LKRNYLINSE VKAKLLHYLN 180
KLVDATEKKI NQALLGASSP KNLDDKVKLS EPFMELVDKD ELPEYYEIVH SPMALSIVKQ 240
NLEIGQYSKI YDFIIDMLLV FQNAHIFNDP SALIYKDATT LTNYFNYLIQ KEFFPELQDL 300
NERGEINLEF DKFEFENYLA IGGGGPAAAG ALAISALDND IEPESNREDL IDQADYDFNH 360
FEGLGNGYNR SLLTEDYLLN PNNFKKLIAK PETVQSEVKN ERSTTSDIEK TNSLESEHLK 420
IPKYNVIKSM QKEMQSLSEQ HTMEYKPYKL IQQIYIFSSK NLYSQATKPL LGSRPSCNQN 480
WVEYIFNGNE LSQNENAFSF MLQPMQTFLT LQSHLTSSLK DTETLLTINK EPVKSRTSNV 540
NSNLSQPQQQ ENDVIGNDTK QDIENLTIGG GNNNDIVGND NDKRNNITEI FDIRLSEGLN 600
HLMFRCEDKI SHETEFMNFW INVLP 625 |
Gene Ontology | GO:0016586; C:RSC complex; IDA:UniProtKB. GO:0070577; F:histone acetyl-lysine binding; IDA:SGD. GO:0043044; P:ATP-dependent chromatin remodeling; IDA:UniProtKB. GO:0000086; P:G2/M transition of mitotic cell cycle; IMP:SGD. GO:0006337; P:nucleosome disassembly; IDA:SGD. GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW. GO:0006368; P:transcription elongation from RNA polymerase II promoter; IDA:SGD. |
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