CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018080
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Smith-Magenis syndrome chromosomal region candidate gene 8 protein 
Protein Synonyms/Alias
  
Gene Name
 SMCR8 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
198FAGELEKKLKDLDYTubiquitination[1]
251IEHQDLLKQIRSYPHubiquitination[1]
815SILDLDNKTLRCPLYubiquitination[1, 2, 3]
936YVPSFLYKI******ubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 
Functional Description
  
Sequence Annotation
 MOD_RES 468 468 Phosphoserine.
 MOD_RES 471 471 Phosphoserine.
 MOD_RES 489 489 Phosphoserine (By similarity).
 MOD_RES 492 492 Phosphoserine.
 MOD_RES 498 498 Phosphoserine.  
Keyword
 Alternative splicing; Complete proteome; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 937 AA 
Protein Sequence
MISAPDVVAF TKEEEYEEEP YNEPALPEEY SVPLFPFASQ GANPWSKLSG AKFSRDFILI 60
SEFSEQVGPQ PLLTIPNDTK VFGTFDLNYF SLRIMSVDYQ ASFVGHPPGS AYPKLNFVED 120
SKVVLGDSKE GAFAYVHHLT LYDLEARGFV RPFCMAYISA DQHKIMQQFQ ELSAEFSRAS 180
ECLKTGNRKA FAGELEKKLK DLDYTRTVLH TETEIQKKAN DKGFYSSQAI EKANELASVE 240
KSIIEHQDLL KQIRSYPHRK LKGHDLCPGE MEHIQDQASQ ASTTSNPDES ADTDLYTCRP 300
AYTPKLIKAK STKCFDKKLK TLEELCDTEY FTQTLAQLSH IEHMFRGDLC YLLTSQIDRA 360
LLKQQHITNF LFEDFVEVDD RMVEKQESIP SKPSQDRPPS SSLEECPIPK VLISVGSYKS 420
SVESVLIKME QELGDEEYKE VEVTELSSFD PQENLDYLDM DMKGSISSGE SIEVLGTEKS 480
TSVLSKSDSQ ASLTVPLSPQ VVRSKAVSHR TISEDSIEVL STCPSEALIP DDFKASYPSA 540
INEEESYPDG NEGAIRFQAS ISPPELGETE EGSIENTPSQ IDSSCCIGKE SDGQLVLPST 600
PAHTHSDEDG VVSSPPQRHR QKDQGFRVDF SVENANPSSR DNSCEGFPAY ELDPSHLLAS 660
RDISKTSLDN YSDTTSYVSS VASTSSDRIP SAYPAGLSSD RHKKRAGQNA LKFIRQYPFA 720
HPAIYSLLSG RTLVVLGEDE AIVRKLVTAL AIFVPSYGCY AKPVKHWASS PLHIMDFQKW 780
KLIGLQRVAS PAGAGTLHAL SRYSRYTSIL DLDNKTLRCP LYRGTLVPRL ADHRTQIKRG 840
STYYLHVQSM LTQLCSKAFL YTFCHHLHLP THDKETEELV ASRQMSFLKL TLGLVNEDVR 900
VVQYLAELLK LHYMQESPGT SHPMLRFDYV PSFLYKI 937 
Gene Ontology
 GO:0005634; C:nucleus; IDA:HPA. 
Interpro
 IPR021713; Folliculin. 
Pfam
 PF11704; Folliculin 
SMART
  
PROSITE
  
PRINTS