CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038730
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Tyrosine-protein kinase receptor 
Protein Synonyms/Alias
  
Gene Name
 Pdgfrb 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
649STARSSEKQALMSELubiquitination[1]
766LDMKGDIKYADIESPubiquitination[1]
845ICEGKLVKICDFGLAubiquitination[1]
864RDSNYISKGSTFLPLubiquitination[1]
972LLGEGYKKKYQQVDEubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1103 AA 
Protein Sequence
MEDTMGLPGV IPALVLRGQL LLSVLWLLGP QTSRGLVITP PGPEFVLNIS STFVLTCSGS 60
APVMWEQMSQ VPWQEAAMNQ DGTFSSVLTL TNVTGGDTGE YFCVYNNSLG PELSERKRIY 120
IFVPDPTMGF LPMDSEDLFI FVTDVTETTI PCRVTDPQLE VTLHEKKVDI PLHVPYDHQR 180
GFTGTFEDKT YICKTTIGDR EVDSDTYYVY SLQVSSINVS VNAVQTVVRQ GESITIRCIV 240
MGNDVVNFQW TYPRMKSGRL VEPVTDYLFG VPSRIGSILH IPTAELSDSG TYTCNVSVSV 300
NDHGDEKAIN ISVIENGYVR LLETLGDVEI AELHRSRTLR VVFEAYPMPS VLWLKDNRTL 360
GDSGAGELVL STRNMSETRY VSELILVRVK VSEAGYYTMR AFHEDDEVQL SFKLQVNVPV 420
RVLELSESHP ANGEQTIRCR GRGMPQPNVT WSTCRDLKSR CPRKLSPTPL GNSSKEESQL 480
ETNVTFWEED QEYEVVSTLR LRHVDQPLSV RCMLQNSMGG DSQEVTVVPH SLPFKVVVIS 540
AILALVVLTV ISLIILIMLW QKKPRYEIRW KVIESVSSDG HEYIYVDPVQ LPYDSTWELP 600
RDQLVLGRTL GSGAFGQVVE ATAHGLSHSQ ATMKVAVKML KSTARSSEKQ ALMSELKIMS 660
HLGPHLNVVN LLGACTKGGP IYIITEYCRY GDLVDYLHRN KHTFLQRHSN KHCPPSAELY 720
SNALPVGFSL PSHLNLTGES DGGYMDMSKD ESIDYVPMLD MKGDIKYADI ESPSYMAPYD 780
NYVPSAPERT YRATLINDSP VLSYTDLVGF SYQVANGMDF LASKNCVHRD LAARNVLICE 840
GKLVKICDFG LARDIMRDSN YISKGSTFLP LKWMAPESIF NSLYTTLSDV WSFGILLWEI 900
FTLGGTPYPE LPMNDQFYNA IKRGYRMAQP AHASDEIYEI MQKCWEEKFE TRPPFSQLVL 960
LLERLLGEGY KKKYQQVDEE FLRSDHPAIL RSQARFPGIH SLRSPLDTSS VLYTAVQPNE 1020
SDNDYIIPLP DPKPDVADEG LPEGSPSLAS STLNEVNTSS TISCDSPLEL QEEPQQAEPE 1080
AQLEQPQDSG CPGPLAEAED SFL 1103 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0005887; C:integral to plasma membrane; IEA:InterPro.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0016301; F:kinase activity; IMP:MGI.
 GO:0005019; F:platelet-derived growth factor beta-receptor activity; IEA:InterPro.
 GO:0004871; F:signal transducer activity; IDA:MGI.
 GO:0005021; F:vascular endothelial growth factor-activated receptor activity; IEA:InterPro.
 GO:0030325; P:adrenal gland development; IGI:MGI.
 GO:0001701; P:in utero embryonic development; IMP:MGI.
 GO:0001822; P:kidney development; IMP:MGI.
 GO:0006807; P:nitrogen compound metabolic process; IMP:MGI.
 GO:0035791; P:platelet-derived growth factor receptor-beta signaling pathway; IEA:GOC.
 GO:0050730; P:regulation of peptidyl-tyrosine phosphorylation; IMP:MGI.
 GO:0048705; P:skeletal system morphogenesis; IMP:MGI.
 GO:0048745; P:smooth muscle tissue development; IMP:MGI.
 GO:0001894; P:tissue homeostasis; IMP:MGI.
 GO:0048010; P:vascular endothelial growth factor receptor signaling pathway; IEA:InterPro.
 GO:0038084; P:vascular endothelial growth factor signaling pathway; IEA:GOC. 
Interpro
 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003599; Ig_sub.
 IPR003598; Ig_sub2.
 IPR013151; Immunoglobulin.
 IPR011009; Kinase-like_dom.
 IPR027288; PGFRB.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
 IPR008266; Tyr_kinase_AS.
 IPR020635; Tyr_kinase_cat_dom.
 IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
 IPR001824; Tyr_kinase_rcpt_3_CS.
 IPR009134; Tyr_kinase_VEGFR_rcpt_N. 
Pfam
 PF00047; ig
 PF07714; Pkinase_Tyr 
SMART
 SM00409; IG
 SM00408; IGc2
 SM00219; TyrKc 
PROSITE
 PS50835; IG_LIKE
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00109; PROTEIN_KINASE_TYR
 PS00240; RECEPTOR_TYR_KIN_III 
PRINTS
 PR01832; VEGFRECEPTOR.