CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005932
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Neurotensin receptor type 1 
Protein Synonyms/Alias
 NT-R-1; NTR1; High-affinity levocabastine-insensitive neurotensin receptor; NTRH 
Gene Name
 NTSR1 
Gene Synonyms/Alias
 NTRR 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
398KRPAFSRKADSVSSNubiquitination[1]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol- calcium second messenger system. 
Sequence Annotation
 LIPID 383 383 S-palmitoyl cysteine (Potential).
 CARBOHYD 4 4 N-linked (GlcNAc...) (Potential).
 CARBOHYD 37 37 N-linked (GlcNAc...) (Potential).
 CARBOHYD 41 41 N-linked (GlcNAc...) (Potential).
 DISULFID 141 224 By similarity.  
Keyword
 3D-structure; Cell membrane; Complete proteome; Disulfide bond; G-protein coupled receptor; Glycoprotein; Lipoprotein; Membrane; Palmitate; Polymorphism; Receptor; Reference proteome; Transducer; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 418 AA 
Protein Sequence
MRLNSSAPGT PGTPAADPFQ RAQAGLEEAL LAPGFGNASG NASERVLAAP SSELDVNTDI 60
YSKVLVTAVY LALFVVGTVG NTVTAFTLAR KKSLQSLQST VHYHLGSLAL SDLLTLLLAM 120
PVELYNFIWV HHPWAFGDAG CRGYYFLRDA CTYATALNVA SLSVERYLAI CHPFKAKTLM 180
SRSRTKKFIS AIWLASALLA VPMLFTMGEQ NRSADGQHAG GLVCTPTIHT ATVKVVIQVN 240
TFMSFIFPMV VISVLNTIIA NKLTVMVRQA AEQGQVCTVG GEHSTFSMAI EPGRVQALRH 300
GVRVLRAVVI AFVVCWLPYH VRRLMFCYIS DEQWTPFLYD FYHYFYMVTN ALFYVSSTIN 360
PILYNLVSAN FRHIFLATLA CLCPVWRRRR KRPAFSRKAD SVSSNHTLSS NATRETLY 418 
Gene Ontology
 GO:0005783; C:endoplasmic reticulum; TAS:ProtInc.
 GO:0005794; C:Golgi apparatus; TAS:ProtInc.
 GO:0005887; C:integral to plasma membrane; TAS:ProtInc.
 GO:0016492; F:G-protein coupled neurotensin receptor activity; IEA:InterPro.
 GO:0004930; F:G-protein coupled receptor activity; TAS:ProtInc.
 GO:0008344; P:adult locomotory behavior; IEA:Compara.
 GO:0007268; P:synaptic transmission; TAS:ProtInc. 
Interpro
 IPR000276; GPCR_Rhodpsn.
 IPR017452; GPCR_Rhodpsn_7TM.
 IPR003985; NT1_rcpt.
 IPR003984; NT_rcpt. 
Pfam
 PF00001; 7tm_1 
SMART
  
PROSITE
 PS00237; G_PROTEIN_RECEP_F1_1
 PS50262; G_PROTEIN_RECEP_F1_2 
PRINTS
 PR00237; GPCRRHODOPSN.
 PR01479; NEUROTENSINR.
 PR01480; NEUROTENSN1R.