CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-003183
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 FKBP-type 22 kDa peptidyl-prolyl cis-trans isomerase 
Protein Synonyms/Alias
 FKBP22; PPIase; Rotamase 
Gene Name
 fklB 
Gene Synonyms/Alias
 ytfC; b4207; JW5746 
Created Date
 July 27, 2013 
Organism
 Escherichia coli (strain K12) 
NCBI Taxa ID
 83333 
Lysine Modification
Position
Peptide
Type
References
86AMAAEGVKYLEENAKacetylation[1]
93KYLEENAKKEGVNSTacetylation[1]
93KYLEENAKKEGVNSTpupylation[2]
130VRVHYTGKLIDGTVFacetylation[1]
Reference
 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618]
 [2] Reconstitution of the Mycobacterium tuberculosis pupylation pathway in Escherichia coli.
 Cerda-Maira FA, McAllister F, Bode NJ, Burns KE, Gygi SP, Darwin KH.
 EMBO Rep. 2011 Jul 8;12(8):863-70. [PMID: 21738222] 
Functional Description
 PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. 
Sequence Annotation
 DOMAIN 120 206 PPIase FKBP-type.  
Keyword
 Complete proteome; Cytoplasm; Direct protein sequencing; Isomerase; Periplasm; Reference proteome; Rotamase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 206 AA 
Protein Sequence
MTTPTFDTIE AQASYGIGLQ VGQQLSESGL EGLLPEALVA GIADALEGKH PAVPVDVVHR 60
ALREIHERAD AVRRQRFQAM AAEGVKYLEE NAKKEGVNST ESGLQFRVIN QGEGAIPART 120
DRVRVHYTGK LIDGTVFDSS VARGEPAEFP VNGVIPGWIE ALTLMPVGSK WELTIPQELA 180
YGERGAGASI PPFSTLVFEV ELLEIL 206 
Gene Ontology
 GO:0005829; C:cytosol; IDA:UniProtKB.
 GO:0016020; C:membrane; IBA:RefGenome.
 GO:0042597; C:periplasmic space; IEA:UniProtKB-SubCell.
 GO:0005528; F:FK506 binding; IBA:RefGenome.
 GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IBA:RefGenome.
 GO:0006457; P:protein folding; IEA:UniProtKB-KW. 
Interpro
 IPR023566; PPIase_FKBP.
 IPR001179; PPIase_FKBP_dom.
 IPR000774; PPIase_FKBP_N. 
Pfam
 PF00254; FKBP_C
 PF01346; FKBP_N 
SMART
  
PROSITE
 PS50059; FKBP_PPIASE 
PRINTS