| Tag | Content |
|---|
| CPLM ID | CPLM-007389 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | ATP-dependent DNA helicase MPH1 |
Protein Synonyms/Alias | Mutator phenotype protein 1 |
Gene Name | MPH1 |
Gene Synonyms/Alias | YIR002C; YIB2C |
Created Date | July 27, 2013 |
Organism | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
NCBI Taxa ID | 559292 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 41 | RRAVPVQKDLHDNVL | acetylation | [1] | | 52 | DNVLPGQKTVYEEIQ | acetylation | [1] |
|
Reference | [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae. Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C. Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [ PMID: 22865919] |
Functional Description | ATP-dependent DNA helicase involved in error-free DNA damage bypass through homologous recombination. |
Sequence Annotation | DOMAIN 94 261 Helicase ATP-binding.
DOMAIN 507 655 Helicase C-terminal.
NP_BIND 107 114 ATP (By similarity).
MOTIF 209 212 DEAH box. |
Keyword | ATP-binding; Complete proteome; DNA damage; DNA repair; DNA-binding; Helicase; Hydrolase; Nucleotide-binding; Nucleus; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 993 AA |
Protein Sequence | MASADDYFSD FEDDELDKLY EKAINKSVKE TITRRAVPVQ KDLHDNVLPG QKTVYEEIQR 60
DVSFGPTHHE LDYDALSFYV YPTNYEVRDY QYTIVHKSLF QNTLCAIPTG MGKTFIASTV 120
MLNYFRWTKK AKIIFTAPTR PLVAQQIKAC LGITGIPSDQ TAILLDKSRK NREEIWANKR 180
VFFATPQVVE NDLKRGVLDP KDIVCLVIDE AHRATGSSAY TNVVKFIDRF NSSYRLLALT 240
ATPASDLEGV QEVVNNLDIS KIEIRTEESM DIVKYMKKRK KEKIEVPLLL EIEDIIEQLG 300
MAVKPVLQQA IELGIYEECD PSQINAFKAM QQSQKIIANP TIPEGIKWRN FFILQLLNNV 360
GQMLKRLKIY GIRTFFNYFQ NKCTEFTTKY NLKKSTNKIA AEFYYHPILK NIKNQCENYL 420
SDPKFVGHGK LQCVRDELMD FFQKRGSDSR VIIFTELRES ALEIVKFIDS VADDQIRPHI 480
FIGQARAKEG FDEVKYTRKH APKGRKKVER LHRQEQEKFL EAERTKRAAN DKLERSARRT 540
GSSEEAQISG MNQKMQKEVI HNFKKGEYNV LVCTSIGEEG LDIGEVDLII CYDTTSSPIK 600
NIQRMGRTGR KRDGKIVLLF SSNESYKFER AMEDYSTLQA LISKQCIDYK KSDRIIPEDI 660
IPECHETLIT INDENEIINE MEDVDEVIRY ATQCMMGKKV KPKKAITKKK RVQENKKPKK 720
FFMPDNVETS IVSASTLINK FLVNESGGKQ LVTSNENPSK KRKIFKALDN LENDSTEEAS 780
SSLETEDEEV SDDNNVFIAE GQNGCQKDLE TAIIRTGESL TTLKPLHNFE RPNMALFVND 840
CGLPTKIEKN VKDIRGNQHN LEKEKSCTVD KNNMVLSLDD WNFFRNRYIP EGVSFDVEPN 900
FVQYTKGVKV PHCHKVSKII TLFNDESNDN KKRTIDMNYT KCLARGMLRD EKKFVKVNDK 960
SQVDNNSVNH DSSQSFTLSN AELDDILGSD SDF 993 |
Gene Ontology | GO:0005634; C:nucleus; IDA:SGD. GO:0043138; F:3'-5' DNA helicase activity; IDA:SGD. GO:0005524; F:ATP binding; IEA:UniProtKB-KW. GO:0070336; F:flap-structured DNA binding; IDA:SGD. GO:0033567; P:DNA replication, Okazaki fragment processing; IGI:SGD. GO:0036297; P:interstrand cross-link repair; IGI:SGD. GO:0060543; P:negative regulation of strand invasion; IDA:SGD. GO:0000725; P:recombinational repair; IMP:SGD. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |