CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028195
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 FI04037p 
Protein Synonyms/Alias
 Rho-kinase 
Gene Name
 rok 
Gene Synonyms/Alias
 rok-RA; CG9774; Dmel_CG9774 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
1371QSTRSSYKPYAVNVQacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1390 AA 
Protein Sequence
MPAGRETVTK QRSMDVERRR RANTLEREMR DPTSICNVDC LLDTVSALVS DCDHESLRRL 60
KNIEQYAAKY KPLAMQINQL RMNVEDFHFI KLIGAGAFGE VQLVRHKSSS QVYAMKRLSK 120
FEMMKRPDSA FFWEERHIMA HANSEWIVQL HFAFQDAKYL YMVMDFMPGG DIVSLMGDYD 180
IPEKWAIFYT MEVVLALDTI HNMGFVHRDV KPDNMLLDSY GHLKLADFGT CMRMGANGQV 240
VSSNAVGTPD YISPEVLQSQ GVDNEYGREC DWWSVGIFLY EMLFGETPFY ADSLVGTYGK 300
IMDHKNSLSF PPEVEISEQA KALIRAFLTD RTQRLGRYGI EDIKAHPFFR NDTWSFDNIR 360
ESVPPVVPEL SSDDDTRNFE DIERDEKPEE VFPVPKGFDG NHLPFIGFTY TGDYQLLSSD 420
TVDAESKEAN VANSGAASNN HGHGHNHRHR PSNSNELKRL EALLERERGR SEALEQQDAG 480
LRQQIELITK REAELQRIAS EYEKDLALRQ HNYKVAMQKV EQEIELRKKT EALLVETQRN 540
LENEQKTRAR DLNINDKVVS LEKQLLEMEQ SYKTETENTQ KLKKHNAELD FTVKSQEEKV 600
RDMVDMIDTL QKHKEELGQE NAELQALVVQ EKNLRSQLKE MHKEAENKMQ TLINDIERTM 660
CREQKAQEDN RALLEKISDL EKAHAGLDFE LKAAQGRYQQ EVKAHQETEK SRLVSREEAN 720
LQEVKALQSK LNEEKSARIK ADQHSQEKER QLSMLSVDYR QIQLRLQKLE GECRQESEKV 780
AALQSQLDQE HSKRNALLSE LSLHSSEVAH LRSRENQLQK ELSTQREAKR RFEEDLTQLK 840
STHHEALANN RELQAQLEAE QCFSRLYKTQ ANENREESAE RLSKIEDLEE ERVSLKHQVQ 900
VAVARADSEA LARSIAEETV ADLEKEKTIK ELELKDFVMK HRNEINAKEA ALATLKEAEN 960
ELHKKLGQKA AEYEDLVQQH KKQQEELALM RSSKDEEITK LLDKCKNEVL LKQVAVNKLA 1020
EVMNRRDSDL PKQKNKARST AELRKKEKEM RRLQQELSQE RDKFNQLLLK HQDLQQLCAE 1080
EQQLKQKMVM EIDCKATEIE NLQSKLNETA SLSSADNDPE DSQHSSLLSL TQDSVFEGWL 1140
SVPNKQNRRR GHGWKRQYVI VSSRKIIFYN SDIDKHNTTD AVLILDLSKV YHVRSVTQGD 1200
VIRADAKEIP RIFQLLYAGE GASHRPDEQS QLDVSVLHGN CNEERPGTIV HKGHEFVHIT 1260
YHMPTACEVC PKPLWHMFKP PAAYECKRCR NKIHKEHVDK HDPLAPCKLN HDPRSARDML 1320
LLAATPEDQS LWVARLLKRI QKSGYKAASY NNNSTDGSKI SPSQSTRSSY KPYAVNVQRS 1380
ATLPANSSLK 1390 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0004674; F:protein serine/threonine kinase activity; IDA:FlyBase.
 GO:0032065; P:cortical protein anchoring; IMP:FlyBase.
 GO:0000910; P:cytokinesis; IDA:FlyBase.
 GO:0007391; P:dorsal closure; TAS:FlyBase.
 GO:0001737; P:establishment of imaginal disc-derived wing hair orientation; IMP:FlyBase.
 GO:0045184; P:establishment of protein localization; IMP:FlyBase.
 GO:0008335; P:female germline ring canal stabilization; IMP:FlyBase.
 GO:0007067; P:mitosis; IMP:FlyBase.
 GO:0000022; P:mitotic spindle elongation; IMP:FlyBase.
 GO:0035191; P:nuclear axial expansion; IMP:FlyBase.
 GO:0007302; P:nurse cell nucleus anchoring; IMP:FlyBase.
 GO:0016318; P:ommatidial rotation; NAS:FlyBase.
 GO:0007309; P:oocyte axis specification; IMP:FlyBase.
 GO:0032231; P:regulation of actin filament bundle assembly; IMP:FlyBase.
 GO:0050770; P:regulation of axonogenesis; IGI:FlyBase.
 GO:0008360; P:regulation of cell shape; IMP:FlyBase.
 GO:2000040; P:regulation of planar cell polarity pathway involved in axis elongation; IDA:FlyBase.
 GO:0001932; P:regulation of protein phosphorylation; IMP:FlyBase.
 GO:0007266; P:Rho protein signal transduction; IPI:FlyBase. 
Interpro
 IPR000961; AGC-kinase_C.
 IPR011009; Kinase-like_dom.
 IPR011993; PH_like_dom.
 IPR017892; Pkinase_C.
 IPR001849; Pleckstrin_homology.
 IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
 IPR000719; Prot_kinase_cat_dom.
 IPR017441; Protein_kinase_ATP_BS.
 IPR020684; Rho-assoc_coiled-coil_kin.
 IPR015008; Rho-bd_dom.
 IPR002290; Ser/Thr_dual-sp_kinase_dom.
 IPR008271; Ser/Thr_kinase_AS. 
Pfam
 PF00069; Pkinase
 PF00433; Pkinase_C
 PF08912; Rho_Binding 
SMART
 SM00109; C1
 SM00233; PH
 SM00133; S_TK_X
 SM00220; S_TKc 
PROSITE
 PS51285; AGC_KINASE_CTER
 PS50003; PH_DOMAIN
 PS00107; PROTEIN_KINASE_ATP
 PS50011; PROTEIN_KINASE_DOM
 PS00108; PROTEIN_KINASE_ST
 PS50081; ZF_DAG_PE_2 
PRINTS