CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028255
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 C12.2, isoform A 
Protein Synonyms/Alias
  
Gene Name
 c12.2 
Gene Synonyms/Alias
 CG12149; Dmel_CG12149 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
1066DTAGLGGKGGPFRLDacetylation[1]
1086HQLSDEEKADVPEEIacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
  
Sequence Annotation
  
Keyword
 ATP-binding; Complete proteome; Hydrolase; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1386 AA 
Protein Sequence
MLANLRACSG HLLHHSLRNA RIPRRSWAST TAGKDQPEED SLTIGDVSVR LRKPKDPQLV 60
PQQYVKYASD GTLQLSQSAL HHLRWMLQKD ALRQDMFLLG QPGPLRRQLA MQFLELTQRE 120
VEYVALSRDT TESDLKQRRE INDRAAIFHD QGAVRAALNG RVLVLDGVEH AERNVLPILN 180
NLLENREMHL ESGKFLMSPE RYDKLLEKHS REQLDEWGLL RVSEQFRVVA LGLPTHKYKG 240
TPLDPPLRSR FQSRNVTTYS YGELYEELQQ EAPSVPGEQL KQLLTFALTL QQADPVLQLP 300
DFPIHNLALG VKMLAANPSL SLHDVISRIY PYQTMLKPDQ KKRVEELLKK LDIQLVPSPS 360
IKKIEAQSQE NSLIHIKLDE LQLNLPEGQI PTASTYFVDL PHQRQALASL LQAYAVGDVC 420
LVGEKGVGKL TLTQELLRLL QQTSEPMMLY EDMTSRDIVQ QRITSPQGDT VWRDSPLVRA 480
AKSGSVAVLN GLHRLHKSTA SVLQRLIHDR ELQLCDGTTL LGANRYQALL QQGFSKEELG 540
KLGFLPIHES FRVVALAEPP RLGGGQPSWL TPELLSLFLY QELRPLRQSE EAELLAQLCG 600
GDLPAGMDQL LKLAQLLRSS QDPLLQGLAG TLSTRQLLKL ARRLAAYPES ELSDVHEMLQ 660
NTFLARFMPA LSRGALEQAI QQVGIKPREI KLKSKKNQIA VEDNSLRIGS TRWPLGNPTQ 720
AQLSKVPHTL FYEMPQHVQL LERLLQDYLI GEHLLLVGNQ GVGKNKLVDR LLELMQRPRE 780
YIQLHRDTTV HSLTLQATLK DGQVSYEDSA LVQAVRTGHV LVVDEADKAP VNVTCILRTL 840
VESGEMVLAD GRRIVPPGEG GRVPNSIETH PDFRLIVLAN RPGFPFLGND FFAALGDVFS 900
CHAISNPDPE SEIFLLQQYG PKVPIKTLRT LVNAFGELRT LADEGMLNYP YSTREVVSIV 960
KHLERYPEEN MSEVVGNVLD FDRYQPEALQ QVTQVLAKHG IESYAEEEIQ AIRKQRILQA 1020
SVNRHSGLGV SGPKFGKLDP KNEPHVGGNT WAGGSGGRDT AGLGGKGGPF RLDKGHKVHQ 1080
LSDEEKADVP EEIKRAAREM NRKAFEDKLK EIKMSAHDHK LYAQFSEPNR KQVQQLKAVL 1140
EAMQTKSKER QWQKYQTHGD LDDTRLVEGI TGEKNIYRRR AEANPWADHV QEKPNRLKLV 1200
VDVSGSMYRF NGYDGRLDRQ LEAVVMVMEA FEGFEKKIVY DIIGHSGEGW EIPFVTAGSP 1260
PKNDKERFEA IRMMHAHSQF CWSGDSTVKA AREACSTLGA EQDYDNAIVV VLSDANLQRY 1320
GIAPKDLAMA LKRGEPKVKG YAIFIGSLAE EADEINAEMP AGQSFVCMDL TKLPHILQQI 1380
FTSSLL 1386 
Gene Ontology
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0016887; F:ATPase activity; IEA:EC.
 GO:0006200; P:ATP catabolic process; IEA:GOC. 
Interpro
 IPR003593; AAA+_ATPase.
 IPR011704; ATPase_dyneun-rel_AAA.
 IPR027417; P-loop_NTPase.
 IPR002035; VWF_A. 
Pfam
 PF07728; AAA_5 
SMART
 SM00382; AAA
 SM00327; VWA 
PROSITE
 PS50234; VWFA 
PRINTS