CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-029375
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Protein phosphatase 2 (Formerly 2A), regulatory subunit A (PR 65), alpha isoform 
Protein Synonyms/Alias
 cDNA FLJ78455, highly similar to Homo sapiens protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform (PPP2R1A), mRNA; cDNA, FLJ96799, Homo sapiens protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform (PPP2R1A), mRNA 
Gene Name
 PPP2R1A 
Gene Synonyms/Alias
 hCG_19686 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
34LRLNSIKKLSTIALAubiquitination[1]
133AHFVPLVKRLAGGDWubiquitination[1]
163PRVSSAVKAELRQYFubiquitination[1, 2]
188VRRAAASKLGEFAKVubiquitination[1, 2]
194SKLGEFAKVLELDNVubiquitination[1]
266VRYMVADKFTELQKAubiquitination[1, 2]
272DKFTELQKAVGPEITubiquitination[1, 2]
280AVGPEITKTDLVPAFubiquitination[1]
307AAASHKVKEFCENLSubiquitination[1, 2]
416VELAEDAKWRVRLAIubiquitination[1]
472NLKKLVEKFGKEWAHubiquitination[1]
475KLVEKFGKEWAHATIubiquitination[1, 2]
485AHATIIPKVLAMSGDubiquitination[1]
542NVRFNVAKSLQKIGPubiquitination[1, 2]
546NVAKSLQKIGPILDNubiquitination[1, 2]
561STLQSEVKPILEKLTubiquitination[1]
Reference
 [1] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [2] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 
Functional Description
  
Sequence Annotation
  
Keyword
  
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 589 AA 
Protein Sequence
MAAADGDDSL YPIAVLIDEL RNEDVQLRLN SIKKLSTIAL ALGVERTRSE LLPFLTDTIY 60
DEDEVLLALA EQLGTFTTLV GGPEYVHCLL PPLESLATVE ETVVRDKAVE SLRAISHEHS 120
PSDLEAHFVP LVKRLAGGDW FTSRTSACGL FSVCYPRVSS AVKAELRQYF RNLCSDDTPM 180
VRRAAASKLG EFAKVLELDN VKSEIIPMFS NLASDEQDSV RLLAVEACVN IAQLLPQEDL 240
EALVMPTLRQ AAEDKSWRVR YMVADKFTEL QKAVGPEITK TDLVPAFQNL MKDCEAEVRA 300
AASHKVKEFC ENLSADCREN VIMSQILPCI KELVSDANQH VKSALASVIM GLSPILGKDN 360
TIEHLLPLFL AQLKDECPEV RLNIISNLDC VNEVIGIRQL SQSLLPAIVE LAEDAKWRVR 420
LAIIEYMPLL AGQLGVEFFD EKLNSLCMAW LVDHVYAIRE AATSNLKKLV EKFGKEWAHA 480
TIIPKVLAMS GDPNYLHRMT TLFCINVLSE VCGQDITTKH MLPTVLRMAG DPVANVRFNV 540
AKSLQKIGPI LDNSTLQSEV KPILEKLTQD QDVDVKYFAQ EALTVLSLA 589 
Gene Ontology
 GO:0005829; C:cytosol; IEA:Compara.
 GO:0000159; C:protein phosphatase type 2A complex; IEA:Compara.
 GO:0004722; F:protein serine/threonine phosphatase activity; IEA:Compara.
 GO:0070262; P:peptidyl-serine dephosphorylation; IEA:Compara.
 GO:0042981; P:regulation of apoptotic process; IEA:Compara. 
Interpro
 IPR011989; ARM-like.
 IPR016024; ARM-type_fold.
 IPR000357; HEAT.
 IPR021133; HEAT_type_2. 
Pfam
 PF02985; HEAT 
SMART
  
PROSITE
 PS50077; HEAT_REPEAT 
PRINTS