UniProt Accession

 FABPH_RAT; P07483; Q9QY04 

Genbank Protein ID

 M18034; J02773; AF144090 

Genbank Nucleotide ID

 AAA41137.1; AAA41136.1; AAF19003.1 

Protein Name

 Fatty acid-binding protein, heart 

Protein Synonyms/Alias

 Fatty acid-binding protein 3; Heart-type fatty acid-binding protein; H-FABP 

Gene Name

 Fabp3 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
10	DAFVGTWKLVDSKNF	acetylation	[1]
15	TWKLVDSKNFDDYMK	acetylation	[1]
22	KNFDDYMKSLGVGFA	acetylation	[1, 2]
38	RQVASMTKPTTIIEK	acetylation	[1]
45	KPTTIIEKNGDTITI	acetylation	[1]
53	NGDTITIKTHSTFKN	acetylation	[1]
59	IKTHSTFKNTEISFQ	acetylation	[2]
82	TADDRKVKSVVTLDG	acetylation	[1]
91	VVTLDGGKLVHVQKW	acetylation	[1]
97	GKLVHVQKWDGQETT	acetylation	[1]
113	TRELSDGKLILTLTH	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Role of portal region lysine residues in electrostatic interactions between heart fatty acid binding protein and phospholipid membranes.
 Herr FM, Aronson J, Storch J.
 Biochemistry. 1996 Jan 30;35(4):1296-303. [PMID: 8573586] 

Functional Description

 FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. 

Sequence Annotation

 BINDING 127 127 Fatty acid (By similarity).
 BINDING 129 129 Fatty acid (By similarity).
 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 20 20 Phosphotyrosine; by Tyr-kinases.  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Lipid-binding; Phosphoprotein; Reference proteome; Transport. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 133 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:RGD.
 GO:0016528; C:sarcoplasm; IDA:RGD.
 GO:0050543; F:icosatetraenoic acid binding; IPI:RGD.
 GO:0005324; F:long-chain fatty acid transporter activity; IPI:RGD.
 GO:0006635; P:fatty acid beta-oxidation; NAS:RGD.
 GO:0042493; P:response to drug; IEP:RGD.
 GO:0070542; P:response to fatty acid; IEP:RGD.
 GO:0032868; P:response to insulin stimulus; IEP:RGD. 

Interpro

 IPR012674; Calycin.
 IPR011038; Calycin-like.
 IPR000463; Fatty_acid-bd.
 IPR000566; Lipocln_cytosolic_FA-bd_dom. 

Pfam

 PF00061; Lipocalin 

SMART

  

PROSITE

 PS00214; FABP 

PRINTS

 PR00178; FATTYACIDBP.