CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-042161
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Uncharacterized protein 
Protein Synonyms/Alias
  
Gene Name
 LOC100727418 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Cavia porcellus (Guinea pig) 
NCBI Taxa ID
 10141 
Lysine Modification
Position
Peptide
Type
References
43DVFVPDDKEEFVKAKacetylation[1]
67TAETEHGKTVTVREDacetylation[1]
278SRVIFQLKAERDYHIacetylation[1]
383DGTEEADKSAYLMGLacetylation[1]
405GLCHPRVKVGNEYVTacetylation[1]
413VGNEYVTKGQNVQQVacetylation[1]
434LAKAVYEKMFNWMVGacetylation[1]
565GKSSNFQKPRNIKGKacetylation[1]
744DSRKGAEKLLGSLDIacetylation[1]
757DIDHNQYKFGHTKVFacetylation[1]
1016DLQAEEDKVNTLTKAacetylation[1]
1026TLTKAKVKLEQQVDDacetylation[1]
1042EGSLEQEKKVRMDLEacetylation[1]
1106ALGSQLQKKLKELQAacetylation[1]
1247KAKANLEKMCRTLEDacetylation[1]
1279DLTSQRAKLQTENGEacetylation[1]
1294LSRQLDEKEALISQLacetylation[1]
1316TQQLEDLKRQLEEEVacetylation[1]
1354YEEETEAKAELQRVLacetylation[1]
1444AAAAALDKKQRNFDKacetylation[1]
1445AAAALDKKQRNFDKIacetylation[1]
1459ILAEWKQKYEESQSEacetylation[1]
1499LEHLETFKRENKNLQacetylation[1]
1528KSIHELEKIRKQLEAacetylation[1]
1531HELEKIRKQLEAEKLacetylation[1]
1569QLEFNQIKAEIERKLacetylation[1]
1579IERKLAEKDEEMEQAacetylation[1]
1587DEEMEQAKRNHLRVVacetylation[1]
1641RLAAEAQKQVKSLQSacetylation[1]
1727NTSLINQKKKMDADLacetylation[1]
1791KNMEQTIKDLQHRLDacetylation[1]
1930KSRDIGTKGLNEE**acetylation[1]
Reference
 [1] The cardiac acetyl-lysine proteome.
 Foster DB, Liu T, Rucker J, O'Meally RN, Devine LR, Cole RN, O'Rourke B.
 PLoS One. 2013;8(7):e67513. [PMID: 23844019] 
Functional Description
  
Sequence Annotation
  
Keyword
 Actin-binding; ATP-binding; Coiled coil; Complete proteome; Motor protein; Myosin; Nucleotide-binding; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1935 AA 
Protein Sequence
MGDSEMAAFG AAAPYLRKSE KERLEAQTRP FDLKKDVFVP DDKEEFVKAK IVSREGGKVT 60
AETEHGKTVT VREDQIMQQN PPKFDKIEDM AMLTFLHEPA VLYNLKERYA SWMIYTYSGL 120
FCVTVNPYKW LPVYNAEVVA AYRGKKRSEA PPHIFSISDN AYQYMLTDRE NQSILITGES 180
GAGKTVNTKR VIQYFAVIAA IGDRSKKEQT PGKGTLEDQI IQANPALEAF GNAKTVRNDN 240
SSRFGKFIRI HFGATGKLAS ADIETYLLEK SRVIFQLKAE RDYHIFYQIL SNKKPELLDM 300
LLITNNPYDY AFISQGETTV ASIDDSEELM ATDNAFDVLG FTPEEKNSMY KLTGAIMHFG 360
NMKFKQKQRE EQAEPDGTEE ADKSAYLMGL NSADLLKGLC HPRVKVGNEY VTKGQNVQQV 420
AYATGALAKA VYEKMFNWMV GRINATLETK QPRQYFIGVL DIAGFEIFDF NSFEQLCINF 480
TNEKLQQFFN HHMFVLEQEE YKKEGIEWEF IDFGMDLQAC IDLIEKPMGI MSILEEECMF 540
PKATDMTFKA KLFDNHLGKS SNFQKPRNIK GKPEAHFSLI HYAGTVDYNI IGWLQKNKDP 600
LNETVVALYQ KSSLKLLSNL FANYAGADAP VEKGKGKAKK GSSFQTVSAL HRENLNKLMT 660
NLRSTHPHFV RCIIPNETKS PGVIDNPLVM HQLRCNGVLE GIRICRKGFP NRILYGDFRQ 720
RYRILNPAAI PEGQFIDSRK GAEKLLGSLD IDHNQYKFGH TKVFFKAGLL GLLEEMRDER 780
LSRIITRIQA QSRGVLSRME YKKLLERRDS LLIIQWNIRS FMSVKNWPWM KLFFKIKPLL 840
KSAETEKEMA TMKEEFARIK EALEKSEARR KELEEKMVSL LQEKNDLQLQ VQTEQDNLAD 900
AEERCDQLIK NKIQLEAKVK EMNERLEDEE EMNAELTAKK RKLEDECSEL KRDIDDLELT 960
LAKVEKEKHA TENKVKNLTE EMAGLDEIIV KLTKEKKALQ EAHQQALDDL QAEEDKVNTL 1020
TKAKVKLEQQ VDDLEGSLEQ EKKVRMDLER AKRKLEGDLK LTQESIMDLE NDKQQLDERL 1080
KKKDFELNAL NARIEDEQAL GSQLQKKLKE LQARIEELEE ELEAERTARA KVEKLRSDLS 1140
RELEEISERL EEAGGATSVQ IEMNKKREAE FQKMRRDLEE ATLQHEATAA ALRKKHADSV 1200
AELSEQIDNL QRVKQKLEKE KSEFKLELDD VTSNMEQIIK AKANLEKMCR TLEDQMNEHR 1260
SKAEETQRSV NDLTSQRAKL QTENGELSRQ LDEKEALISQ LTRGKLTYTQ QLEDLKRQLE 1320
EEVKAKNALA HALQSARHDC DLLREQYEEE TEAKAELQRV LSKANSEVAQ WRTKYETDAI 1380
QRTEELEEAK KKLAQRLQDA EEAVEAVNAK CSSLEKTKHR LQNEIEDLMV DVERSNAAAA 1440
ALDKKQRNFD KILAEWKQKY EESQSELESS QKEARSLSTE LFKLKNAYEE SLEHLETFKR 1500
ENKNLQEEIS DLTEQLGSSG KSIHELEKIR KQLEAEKLEL QSALEEAEAS LEHEEGKILR 1560
AQLEFNQIKA EIERKLAEKD EEMEQAKRNH LRVVDSLQTS LDAETRSRNE ALRVKKKMEG 1620
DLNEMEIQLS HANRLAAEAQ KQVKSLQSLL KDTQIQLDDA VRANDDLKEN IAIVERRNNL 1680
LQAELEELRA VVEQTERSRK LAEQELIETS ERVQLLHSQN TSLINQKKKM DADLSQLQTE 1740
VEEAVQECRN AEEKAKKAIT DAAMMAEELK KEQDTSAHLE RMKKNMEQTI KDLQHRLDEA 1800
EQIALKGGKK QLQKLEARVR ELENELEAEQ KRNAESVKGM RKSERRIKEL TYQTEEDRKN 1860
LLRLQDLVDK LQLKVKAYKR QAEEAEEQAN TNLSKFRKVQ HELDEAEERA DIAESQVNKL 1920
RAKSRDIGTK GLNEE 1935 
Gene Ontology
 GO:0005925; C:focal adhesion; IEA:Compara.
 GO:0032982; C:myosin filament; IEA:Compara.
 GO:0005730; C:nucleolus; IEA:Compara.
 GO:0001725; C:stress fiber; IEA:Compara.
 GO:0030018; C:Z disc; IEA:Compara.
 GO:0030898; F:actin-dependent ATPase activity; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0003774; F:motor activity; IEA:InterPro.
 GO:0008307; F:structural constituent of muscle; IEA:Compara.
 GO:0007512; P:adult heart development; IEA:Compara.
 GO:0030049; P:muscle filament sliding; IEA:Compara.
 GO:0002027; P:regulation of heart rate; IEA:Compara.
 GO:0055010; P:ventricular cardiac muscle tissue morphogenesis; IEA:Compara. 
Interpro
 IPR000048; IQ_motif_EF-hand-BS.
 IPR027401; Myosin-like_IQ_dom.
 IPR001609; Myosin_head_motor_dom.
 IPR004009; Myosin_N.
 IPR002928; Myosin_tail.
 IPR027417; P-loop_NTPase. 
Pfam
 PF00063; Myosin_head
 PF02736; Myosin_N
 PF01576; Myosin_tail_1 
SMART
 SM00015; IQ
 SM00242; MYSc 
PROSITE
 PS50096; IQ 
PRINTS
 PR00193; MYOSINHEAVY.