CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-033193
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Succinate-semialdehyde dehydrogenase, mitochondrial 
Protein Synonyms/Alias
  
Gene Name
 ALDH5A1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
251CTDPLVSKISFTGSTubiquitination[1]
359QGPLINEKAVEKVEKacetylation[2]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Oxidoreductase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 507 AA 
Protein Sequence
MATCIWLRSC GARRLGSTFP GCRLRPRAGG LVPASGPAPG PAQLRCYAGR LAGLSAALLR 60
TDSFVGGRWL PAAATFPVQD PASGAALGMV ADCGVREARA AVRAAYEAFC RWREVSAKGK 120
PLKEAHGEIL YSAFFLEWFS EEARRVYGDI IHTPAKDRRA LVLKQPIGVA AVITPWNFPS 180
AMITRKVGAA LAAGCTVVVK PAEDTPFSAL ALAELASQAG IPSGVYNVIP CSRKNAKEVG 240
EAICTDPLVS KISFTGSTTT GKILLHHAAN SVKRVSMELG GLAPFIVFDS ANVDQAVAGA 300
MASKFRNTGQ TCVCSNQFLV QRGIHDAFVK AFAEAMKKNL RVGNGFEEGT TQGPLINEKA 360
VEKVEKQVND AVSKGATVVT GGKRHQLGKN FFEPTLLCNV TQDMLCTHEE TFGPLAPVIK 420
FDTEEEAIAI ANAADVGLAG YFYSQDPAQI WRVAEQLEVG MVGVNEGLIS SVECPFGGVK 480
QSGLGREGSK YGIDEYLELK YVCYGGL 507 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:HPA.
 GO:0009013; F:succinate-semialdehyde dehydrogenase [NAD(P)+] activity; IEA:InterPro.
 GO:0009450; P:gamma-aminobutyric acid catabolic process; IEA:InterPro. 
Interpro
 IPR016161; Ald_DH/histidinol_DH.
 IPR016163; Ald_DH_C.
 IPR016160; Ald_DH_CS.
 IPR016162; Ald_DH_N.
 IPR015590; Aldehyde_DH_dom.
 IPR010102; Succ_semiAld_DH. 
Pfam
 PF00171; Aldedh 
SMART
  
PROSITE
 PS00070; ALDEHYDE_DEHYDR_CYS
 PS00687; ALDEHYDE_DEHYDR_GLU 
PRINTS