UniProt Accession

 HNMT_RAT; Q01984; Q59JM9 

Genbank Protein ID

 D10693; AB007834; BC087635 

Genbank Nucleotide ID

 BAA01535.1; BAB84319.1; AAH87635.1 

Protein Name

 Histamine N-methyltransferase 

Protein Synonyms/Alias

 HMT 

Gene Name

 Hnmt 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
99	AEQIVKYKELVAKTS	acetylation	[1]
112	TSNMENIKFAWHKET	acetylation	[1]
117	NIKFAWHKETSSEYQ	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine. 

Sequence Annotation

 BINDING 28 28 Substrate (By similarity).
 BINDING 60 60 S-adenosyl-L-methionine; via carbonyl
 BINDING 89 89 S-adenosyl-L-methionine (By similarity).
 BINDING 94 94 S-adenosyl-L-methionine (By similarity).
 BINDING 120 120 S-adenosyl-L-methionine; via amide
 BINDING 143 143 S-adenosyl-L-methionine; via carbonyl
 BINDING 284 284 Substrate (By similarity).
 MOD_RES 2 2 Blocked amino end (Ala).
 MOD_RES 3 3 Phosphoserine (By similarity).
 MOD_RES 10 10 Phosphoserine (By similarity).
 MOD_RES 18 18 Phosphoserine (By similarity).  

Keyword

 Complete proteome; Cytoplasm; Direct protein sequencing; Methyltransferase; Phosphoprotein; Reference proteome; S-adenosyl-L-methionine; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 295 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0043005; C:neuron projection; IDA:RGD.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0046539; F:histamine N-methyltransferase activity; IDA:RGD.
 GO:0007420; P:brain development; IEP:RGD.
 GO:0006972; P:hyperosmotic response; IEP:RGD.
 GO:0014075; P:response to amine stimulus; IEP:RGD.
 GO:0042220; P:response to cocaine; IEP:RGD.
 GO:0051384; P:response to glucocorticoid stimulus; IEP:RGD.
 GO:0070555; P:response to interleukin-1; IEP:RGD.
 GO:0002347; P:response to tumor cell; IEP:RGD. 

Interpro

 IPR016673; Histamine_N-methyltransferase. 

Pfam

  

SMART

  

PROSITE

  

PRINTS