UniProt Accession

 DAPF_ECOLI; P0A6K1; P08885; P78126; Q2M8B5; Q8X8P8 

Genbank Protein ID

 X12968; M87049; U00096; AP009048; M38257; X66782 

Genbank Nucleotide ID

 CAA31413.1; AAA67605.1; AAC76812.2; BAE77491.1; AAA24761.1; CAA47282.1 

Protein Name

 Diaminopimelate epimerase 

Protein Synonyms/Alias

 DAP epimerase 

Gene Name

 dapF 

Gene Synonyms/Alias

 b3809; JW5592 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
198	IGFMQVVKREHIRLR	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Catalyzes the stereoinversion of LL-2,6- diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso- DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan. Only accepts DAP isomers with the L configuration. 

Sequence Annotation

 REGION 8 9 Substrate (By similarity).
 REGION 73 75 Substrate binding (By similarity).
 REGION 208 209 Substrate binding (By similarity).
 REGION 218 219 Substrate binding (By similarity).
 ACT_SITE 73 73 Proton donor/acceptor (By similarity).
 ACT_SITE 217 217 Proton donor/acceptor (By similarity).
 BINDING 11 11 Substrate (By similarity).
 BINDING 44 44 Substrate (By similarity).
 BINDING 64 64 Substrate (By similarity).
 BINDING 157 157 Substrate (By similarity).
 BINDING 190 190 Substrate (By similarity).
 DISULFID 73 217 By similarity.  

Keyword

 3D-structure; Amino-acid biosynthesis; Complete proteome; Cytoplasm; Disulfide bond; Isomerase; Lysine biosynthesis; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 274 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0008837; F:diaminopimelate epimerase activity; IEA:HAMAP.
 GO:0009089; P:lysine biosynthetic process via diaminopimelate; IEA:HAMAP. 

Interpro

 IPR018510; DAP_epimerase_AS.
 IPR001653; DAP_epimerase_DapF. 

Pfam

 PF01678; DAP_epimerase 

SMART

  

PROSITE

 PS01326; DAP_EPIMERASE 

PRINTS