UniProt Accession

 RS11_HUMAN; P62280; B2R4F5; P04643; Q498Y6; Q6IRY0 

Genbank Protein ID

 X06617; AB028893; AK311809; CH471177; BC007283; BC007603; BC007945; BC010028; BC016378; BC070224; BC100025; AB007152 

Genbank Nucleotide ID

 CAA29834.1; BAA88215.1; BAG34752.1; EAW52497.1; AAH07283.1; AAH07603.1; AAH07945.1; AAH10028.1; AAH16378.1; AAH70224.1; AAI00026.1; BAA25818.1 

Protein Name

 40S ribosomal protein S11 

Protein Synonyms/Alias

  

Gene Name

 RPS11 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
12	QTERAYQKQPTIFQN	ubiquitination	[1, 2, 3, 4, 5, 6]
20	QPTIFQNKKRVLLGE	ubiquitination	[5]
21	PTIFQNKKRVLLGET	ubiquitination	[5]
30	VLLGETGKEKLPRYY	acetylation	[7]
30	VLLGETGKEKLPRYY	ubiquitination	[2, 5]
32	LGETGKEKLPRYYKN	sumoylation	[8]
32	LGETGKEKLPRYYKN	ubiquitination	[5]
38	EKLPRYYKNIGLGFK	acetylation	[9]
38	EKLPRYYKNIGLGFK	ubiquitination	[1, 2, 4, 5, 6, 10, 11]
45	KNIGLGFKTPKEAIE	acetylation	[9]
45	KNIGLGFKTPKEAIE	ubiquitination	[2, 3, 4, 5, 11]
48	GLGFKTPKEAIEGTY	ubiquitination	[1, 2, 5, 6]
58	IEGTYIDKKCPFTGN	ubiquitination	[2, 4, 5]
59	EGTYIDKKCPFTGNV	ubiquitination	[1, 5, 6]
79	ILSGVVTKMKMQRTI	ubiquitination	[1, 2, 4, 5, 6]
107	NRFEKRHKNMSVHLS	ubiquitination	[4, 5]
136	GECRPLSKTVRFNVL	ubiquitination	[1, 4, 5, 6]
144	TVRFNVLKVTKAAGT	ubiquitination	[2, 4, 5, 11]
153	TKAAGTKKQFQKF**	ubiquitination	[5]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Ubiquitin ligase substrate identification through quantitative proteomics at both the protein and peptide levels.
 Lee KA, Hammerle LP, Andrews PS, Stokes MP, Mustelin T, Silva JC, Black RA, Doedens JR.
 J Biol Chem. 2011 Dec 2;286(48):41530-8. [PMID: 21987572]
 [4] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [5] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [6] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [7] Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome.
 Morselli E, Mariño G, Bennetzen MV, Eisenberg T, Megalou E, Schroeder S, Cabrera S, Bénit P, Rustin P, Criollo A, Kepp O, Galluzzi L, Shen S, Malik SA, Maiuri MC, Horio Y, López-Otín C, Andersen JS, Tavernarakis N, Madeo F, Kroemer G.
 J Cell Biol. 2011 Feb 21;192(4):615-29. [PMID: 21339330]
 [8] Targeted identification of SUMOylation sites in human proteins using affinity enrichment and paralog-specific reporter ions.
 Lamoliatte F, Bonneil E, Durette C, Caron-Lizotte O, Wildemann D, Zerweck J, Wenschuh H, Thibault P.
 Mol Cell Proteomics. 2013 Jun 7;. [PMID: 23750026]
 [9] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [10] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [11] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 

Functional Description

  

Sequence Annotation

 MOD_RES 2 2 N-acetylalanine.
 MOD_RES 38 38 N6-acetyllysine.
 MOD_RES 45 45 N6-acetyllysine.
 LIPID 60 60 S-palmitoyl cysteine (Probable).  

Keyword

 3D-structure; Acetylation; Complete proteome; Direct protein sequencing; Lipoprotein; Palmitate; Reference proteome; Ribonucleoprotein; Ribosomal protein; RNA-binding; rRNA-binding. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 158 AA 

Protein Sequence

Gene Ontology

 GO:0022627; C:cytosolic small ribosomal subunit; IDA:UniProtKB.
 GO:0019843; F:rRNA binding; IEA:UniProtKB-KW.
 GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
 GO:0000184; P:nuclear-transcribed mRNA catabolic process, nonsense-mediated decay; TAS:Reactome.
 GO:0006614; P:SRP-dependent cotranslational protein targeting to membrane; TAS:Reactome.
 GO:0006414; P:translational elongation; TAS:Reactome.
 GO:0006413; P:translational initiation; TAS:Reactome.
 GO:0006415; P:translational termination; TAS:Reactome.
 GO:0019083; P:viral transcription; TAS:Reactome. 

Interpro

 IPR012340; NA-bd_OB-fold.
 IPR000266; Ribosomal_S17.
 IPR019978; Ribosomal_S17_archaeal.
 IPR019979; Ribosomal_S17_CS. 

Pfam

 PF00366; Ribosomal_S17 

SMART

  

PROSITE

 PS00056; RIBOSOMAL_S17 

PRINTS

 PR00973; RIBOSOMALS17.