CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013751
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Probable proline--tRNA ligase, mitochondrial 
Protein Synonyms/Alias
 Prolyl-tRNA synthetase; ProRS 
Gene Name
 Pars2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
171ALVASQKKLSYKQLPacetylation[1]
175SQKKLSYKQLPLLLYacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 
Functional Description
  
Sequence Annotation
  
Keyword
 Aminoacyl-tRNA synthetase; ATP-binding; Complete proteome; Ligase; Mitochondrion; Nucleotide-binding; Protein biosynthesis; Reference proteome; Transit peptide. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 475 AA 
Protein Sequence
MEGLLTRCRT LSALATCSLR HSRCIVRKCY HCAPGRGQRL VVSRMFQPQN LREDQVLSLE 60
GRASDLTCKS QRLMLQVGLI LPASPGCYHL MPYTVRAVEK LVRVIDQEMQ AIGGQKINMP 120
SLSPAELWRA TGRWDLMGRE LLRLKDRHGK EYCLGPTHEE AVTALVASQK KLSYKQLPLL 180
LYQVTRKFRD EPRPRFGLLR GREFYMKDMY TFDSSSEAAQ ETYSLVCDAY CRLFDRLGLR 240
WMKARADVGS IGGTMSHEFQ LPVDIGEDRL VVCPSCHFSA NTEIVDLSQK ICPDCQGPLT 300
ETKGIEVGHT FYLGTKYSSI FNAHFTNAHG ESLLAEMGCY GLGVTRILAA AIEVLSTEDC 360
IRWPSLLAPY QVCIIPPKKG SKEAAATEIV ERLYDDVTEA LPQLRGEVLL DDRTHLTIGN 420
RLKDANKLGY PFVIIASKRA LEDPAHFEVW SQNTGEVVFL TKEGVMELLT GVHVV 475 
Gene Ontology
 GO:0005759; C:mitochondrial matrix; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004827; F:proline-tRNA ligase activity; IEA:EC.
 GO:0006433; P:prolyl-tRNA aminoacylation; IEA:InterPro. 
Interpro
 IPR002314; aa-tRNA-synt_IIb_cons-dom.
 IPR006195; aa-tRNA-synth_II.
 IPR004154; Anticodon-bd.
 IPR002316; Pro-tRNA-ligase_IIa.
 IPR004500; Pro-tRNA-synth_IIa_bac-type. 
Pfam
 PF03129; HGTP_anticodon
 PF00587; tRNA-synt_2b 
SMART
  
PROSITE
 PS50862; AA_TRNA_LIGASE_II 
PRINTS
 PR01046; TRNASYNTHPRO.