CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-041704
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Lamin A, isoform CRA_b 
Protein Synonyms/Alias
 Prelamin-A/C 
Gene Name
 Lmna 
Gene Synonyms/Alias
 rCG_62695 
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
32RITRLQEKEDLQELNacetylation[1]
97KTLDSVAKERARLQLacetylation[1]
108RLQLELSKVREEFKEacetylation[1]
114SKVREEFKELKARNTacetylation[1]
135LAAQARLKDLEALLNacetylation[1]
144LEALLNSKEAALSTAacetylation[1]
155LSTALSEKRTLEGELacetylation[1]
171DLRGQVAKLEAALGEacetylation[1]
180EAALGEAKKQLQDEMacetylation[1]
201ENRLQTLKEELDFQKacetylation[1]
208KEELDFQKNIYSEELubiquitination[2]
219SEELRETKRRHETRLacetylation[1]
233LVEIDNGKQREFESRacetylation[1]
260EDQVEQYKKELEKTYacetylation[1]
261DQVEQYKKELEKTYSacetylation[1]
270LEKTYSAKLDNARQSacetylation[1]
311AQLSQLQKQLAAKEAacetylation[1]
316LQKQLAAKEAKLRDLacetylation[1]
319QLAAKEAKLRDLEDSacetylation[1]
341SRRLLAEKEREMAEMacetylation[1]
378MEIHAYRKLLEGEEEacetylation[1]
450EEVDEEGKFVRLRNKacetylation[1]
486MTYRFPPKFTLKAGQacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405]
 [2] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
  
Sequence Annotation
  
Keyword
 Coiled coil; Complete proteome; Intermediate filament; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 665 AA 
Protein Sequence
METPSQRRAT RSGAQASSTP LSPTRITRLQ EKEDLQELND RLAVYIDRVR SLETENAGLR 60
LRITESEEVV SREVSGIKAA YEAELGDARK TLDSVAKERA RLQLELSKVR EEFKELKARN 120
TKKEGDLLAA QARLKDLEAL LNSKEAALST ALSEKRTLEG ELHDLRGQVA KLEAALGEAK 180
KQLQDEMLRR VDAENRLQTL KEELDFQKNI YSEELRETKR RHETRLVEID NGKQREFESR 240
LADALQELRA QHEDQVEQYK KELEKTYSAK LDNARQSAER NSNLVGAAHE ELQQSRIRID 300
SLSAQLSQLQ KQLAAKEAKL RDLEDSLARE RDTSRRLLAE KEREMAEMRA RMQQQLDEYQ 360
ELLDIKLALD MEIHAYRKLL EGEEERLRLS PSPTSQRSRG RASSHSSQSQ GGGSVTKKRK 420
LESSESRSSF SQHARTSGRV AVEEVDEEGK FVRLRNKSNE DQSMGNWQIR RQNGDDPLMT 480
YRFPPKFTLK AGQVVTIWAS GAGATHSPPT DLVWKAQNTW GCGSSLRTAL INATGEEVAM 540
RKLVRSLTMV EDNDDEEEDG DELLHHHRGS HCSSSGDPAE YNLRSRTVLC GTCGQPADKA 600
ASGSGAQVGG SISSGSSASS VTVTRSFRSV GGSGGGSFGD NLVTRSYLLG NSSPRTQSSQ 660
NCSIM 665 
Gene Ontology
 GO:0005638; C:lamin filament; IEA:Compara.
 GO:0005635; C:nuclear envelope; IEA:Compara.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0005198; F:structural molecule activity; IEA:InterPro.
 GO:0071456; P:cellular response to hypoxia; IEA:Compara.
 GO:0030951; P:establishment or maintenance of microtubule cytoskeleton polarity; IEA:Compara.
 GO:0007517; P:muscle organ development; IEA:Compara.
 GO:0006998; P:nuclear envelope organization; IEA:Compara.
 GO:0090343; P:positive regulation of cell aging; IEA:Compara.
 GO:0042981; P:regulation of apoptotic process; IEA:Compara.
 GO:0030334; P:regulation of cell migration; IEA:Compara.
 GO:0035105; P:sterol regulatory element binding protein import into nucleus; IEA:Compara.
 GO:0055015; P:ventricular cardiac muscle cell development; IEA:Compara. 
Interpro
 IPR016044; F.
 IPR001664; IF.
 IPR018039; Intermediate_filament_CS.
 IPR001322; Lamin_tail_dom. 
Pfam
 PF00038; Filament
 PF00932; LTD 
SMART
  
PROSITE
 PS00226; IF 
PRINTS