| Tag | Content |
|---|
| CPLM ID | CPLM-016616 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Sorting nexin-17 |
Protein Synonyms/Alias | |
Gene Name | Snx17 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 178 | GAFSFVRKLQEFELP | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Critical regulator of endosomal recycling of numerous receptors, channels, and other transmembrane proteins. Binds to NPxY sequences in the cytoplasmic tails of target cargos. Plays a role in the sorting of endocytosed LRP1 and APP, and prevents their degradation. Required for maintenance of normal cell surface levels of APP and LRP1. Recycles internalized integrins ITGB1, ITGB5 and their associated alpha subunits, preventing them from lysosomal degradation. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)). |
Sequence Annotation | DOMAIN 1 109 PX.
DOMAIN 115 206 Ras-associating.
REGION 115 432 FERM-like (By similarity).
REGION 270 432 PTB-like F3 module (By similarity).
BINDING 36 36 Phosphatidylinositol 3-phosphate (By
BINDING 38 38 Phosphatidylinositol 3-phosphate; via
BINDING 62 62 Phosphatidylinositol 3-phosphate (By
BINDING 75 75 Phosphatidylinositol 3-phosphate (By
MOD_RES 334 334 Phosphothreonine.
MOD_RES 407 407 Phosphoserine (By similarity).
MOD_RES 409 409 Phosphoserine.
MOD_RES 415 415 Phosphoserine (By similarity).
MOD_RES 421 421 Phosphoserine.
MOD_RES 437 437 Phosphoserine.
MOD_RES 440 440 Phosphoserine. |
Keyword | Complete proteome; Cytoplasm; Cytoplasmic vesicle; Endosome; Lipid-binding; Membrane; Phosphoprotein; Protein transport; Reference proteome; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 470 AA |
Protein Sequence | MHFSIPETES RSGDSGGSAY VAYNIHVNGV LHCRVRYSQL LGLHEQLRKE YGANVVPAFP 60
PKKLFSLTPA EVEQRREQLE KYMQAVRQDP LLGSSETFNS FLRRAQQETQ QVPTEEVSLE 120
VLLSNGQKVL VTVLTSDQTE DVLEAVAAKL DLPDDLIGYF SLFLVREKED GAFSFVRKLQ 180
EFELPYVSVT SLRSQEYKIV LRKSYWDSAY DDDVMENRVG LNLLYAQTVS DIEHGWILVT 240
KEQHRQLKSL QEKVSKKEFL RLAQTLRHYG YLRFDACVAD FPEKDCPVVV SAGNSELSLQ 300
LRLPGQQLRE GSFRVTRMRC WRVTSSVPLP SGGTSSPSRG RGEVRLELAF EYLMSKDRLQ 360
WVTITSPQAI MMSICLQSMV DELMVKKSGG SIRKMLRRRV GGTLRRSDSQ QAVKSPPLLE 420
SPDASRESMV KLSSKLSAVS LRGIGSPSTD ASASAVHGNF AFEGIGDEDL 470 |
Gene Ontology | GO:0016023; C:cytoplasmic membrane-bounded vesicle; ISS:UniProtKB. GO:0030659; C:cytoplasmic vesicle membrane; IEA:UniProtKB-SubCell. GO:0005829; C:cytosol; ISS:UniProtKB. GO:0005769; C:early endosome; IEA:UniProtKB-SubCell. GO:0005768; C:endosome; IPI:MGI. GO:0005794; C:Golgi apparatus; IEA:Compara. GO:0035091; F:phosphatidylinositol binding; ISS:UniProtKB. GO:0015031; P:protein transport; IEA:UniProtKB-KW. GO:0006898; P:receptor-mediated endocytosis; IDA:MGI. GO:0007165; P:signal transduction; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |