CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-039894
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Rho GDP-dissociation inhibitor 2 
Protein Synonyms/Alias
  
Gene Name
 ARHGDIB 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
95TGDLEALKKETIVLKubiquitination[1]
96GDLEALKKETIVLKEubiquitination[2, 3]
102KKETIVLKEGSEYRVacetylation[3]
102KKETIVLKEGSEYRVubiquitination[2, 3]
114YRVKIHFKVNRDIVSubiquitination[2, 3]
124RDIVSGLKYVQHTYRacetylation[3]
124RDIVSGLKYVQHTYRubiquitination[1, 2, 3, 4]
135HTYRTGVKVDKATFMacetylation[3]
Reference
 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302]
 [4] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 159 AA 
Protein Sequence
MTEKAPEPHV EEDDDDELDS KLNYKPPPQK SLKELQEMDK DDESLIKYKK TLLGDGPVVT 60
DPKAPNVVVT RLTLVCESAP GPITMDLTGD LEALKKETIV LKEGSEYRVK IHFKVNRDIV 120
SGLKYVQHTY RTGVKVDKAT FMVGSYGPRP EEYEFLTPV 159 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:InterPro.
 GO:0005094; F:Rho GDP-dissociation inhibitor activity; IEA:InterPro. 
Interpro
 IPR014756; Ig_E-set.
 IPR000406; Rho_GDI.
 IPR024792; RhoGDI_domain. 
Pfam
 PF02115; Rho_GDI 
SMART
  
PROSITE
  
PRINTS
 PR00492; RHOGDI.