| Tag | Content |
|---|
| CPLM ID | CPLM-011219 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | P protein |
Protein Synonyms/Alias | Melanocyte-specific transporter protein; Pink-eyed dilution protein homolog |
Gene Name | OCA2 |
Gene Synonyms/Alias | D15S12; P |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 613 | TNIQELQKKHRISDG | ubiquitination | [1] |
|
Reference | [1] Systematic and quantitative assessment of the ubiquitin-modified proteome. Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP. Mol Cell. 2011 Oct 21;44(2):325-40. [ PMID: 21906983] |
Functional Description | Could be involved in the transport of tyrosine, the precursor to melanin synthesis, within the melanocyte. Regulates the pH of melanosome and the melanosome maturation. One of the components of the mammalian pigmentary system. Seems to regulate the post-translational processing of tyrosinase, which catalyzes the limiting reaction in melanin synthesis. May serve as a key control point at which ethnic skin color variation is determined. Major determinant of brown and/or blue eye color. |
Sequence Annotation | MOD_RES 161 161 Phosphoserine (By similarity).
CARBOHYD 214 214 N-linked (GlcNAc...) (Potential).
CARBOHYD 218 218 N-linked (GlcNAc...) (Potential).
CARBOHYD 273 273 N-linked (GlcNAc...) (Potential).
CARBOHYD 442 442 N-linked (GlcNAc...) (Potential).
CARBOHYD 781 781 N-linked (GlcNAc...) (Potential). |
Keyword | Albinism; Alternative splicing; Complete proteome; Disease mutation; Glycoprotein; Membrane; Phosphoprotein; Polymorphism; Reference proteome; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 838 AA |
Protein Sequence | MHLEGRDGRR YPGAPAVELL QTSVPSGLAE LVAGKRRLPR GAGGADPSHS CPRGAAGQSS 60
WAPAGQEFAS FLTKGRSHSS LPQMSSSRSK DSCFTENTPL LRNSLQEKGS RCIPVYHPEF 120
ITAEESWEDS SADWERRYLL SREVSGLSAS ASSEKGDLLD SPHIRLRLSK LRRCVQWLKV 180
MGLFAFVVLC SILFSLYPDQ GKLWQLLALS PLENYSVNLS SHVDSTLLQV DLAGALVASG 240
PSRPGREEHI VVELTQADAL GSRWRRPQQV THNWTVYLNP RRSEHSVMSR TFEVLTRETV 300
SISIRASLQQ TQAVPLLMAH QYLRGSVETQ VTIATAILAG VYALIIFEIV HRTLAAMLGS 360
LAALAALAVI GDRPSLTHVV EWIDFETLAL LFGMMILVAI FSETGFFDYC AVKAYRLSRG 420
RVWAMIIMLC LIAAVLSAFL DNVTTMLLFT PVTIRLCEVL NLDPRQVLIA EVIFTNIGGA 480
ATAIGDPPNV IIVSNQELRK MGLDFAGFTA HMFIGICLVL LVCFPLLRLL YWNRKLYNKE 540
PSEIVELKHE IHVWRLTAQR ISPASREETA VRRLLLGKVL ALEHLLARRL HTFHRQISQE 600
DKNWETNIQE LQKKHRISDG ILLAKCLTVL GFVIFMFFLN SFVPGIHLDL GWIAILGAIW 660
LLILADIHDF EIILHRVEWA TLLFFAALFV LMEALAHLHL IEYVGEQTAL LIKMVPEEQR 720
LIAAIVLVVW VSALASSLID NIPFTATMIP VLLNLSHDPE VGLPAPPLMY ALAFGACLGG 780
NGTLIGASAN VVCAGIAEQH GYGFSFMEFF RLGFPMMVVS CTVGMCYLLV AHVVVGWN 838 |
Gene Ontology | GO:0005789; C:endoplasmic reticulum membrane; IDA:UniProtKB. GO:0010008; C:endosome membrane; IDA:UniProtKB. GO:0016021; C:integral to membrane; TAS:ProtInc. GO:0005765; C:lysosomal membrane; IDA:UniProtKB. GO:0033162; C:melanosome membrane; IDA:UniProtKB. GO:0005302; F:L-tyrosine transmembrane transporter activity; TAS:ProtInc. GO:0008283; P:cell proliferation; IEA:Compara. GO:0006726; P:eye pigment biosynthetic process; TAS:ProtInc. GO:0042438; P:melanin biosynthetic process; IEA:Compara. GO:0030318; P:melanocyte differentiation; IEA:Compara. GO:0007286; P:spermatid development; IEA:Compara. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |