CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-029883
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Mediator of RNA polymerase II transcription subunit 1 
Protein Synonyms/Alias
 Peroxisome proliferator activated receptor binding protein, isoform CRA_a 
Gene Name
 Med1 
Gene Synonyms/Alias
 Pparbp; mCG_21903 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
202TNAAPLDKILHGSVGubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Receptor; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 629 AA 
Protein Sequence
MKAQGETEDS ERLSKMSSLL ERLHAKFNQN RPWSETIKLV RQVMEKRVVM SSGGHQHLVS 60
CLETLQKALK VTSLPAMTDR LESIARQNGL GSHLSASGTE CYITSDMFYV EVQLDPAGQL 120
CDVKVAHHGE NPVSCPELVQ QLREKNFEEF SKHLKGLVNL YNLPGDNKLK TKMYLALQSL 180
EQDLSKMAIM YWKATNAAPL DKILHGSVGY LTPRSGGHLM NMKYYASPSD LLDDKTASPI 240
ILHEKNVPRS LGMNASVTIE GTSAMYKLPI APLIMGSHPA DNKWTPSFSA VTSANSVDLP 300
ACFFLKFPQP IPVSKAFVQK LQNCTGIPLF ETPPTYLPLY ELITQFELSK DPDPLPLNHN 360
MRFYAALPGQ QHCYFLNKDA PLPDGQSLQG TLVSKITFQH PGRVPLILNM IRHQVAYNTL 420
IGSCVKRTIL KEDSPGLLQF EVCPLSESRF SVSFQHPVND SLVCVVMDVQ DSTHVSCKLY 480
KGLSDALICT DDFIAKVVQR CMSIPVTMRA IRRKAETIQA DTPALSLIAE TVEDMVKKNL 540
PPASSPGVEE KRQDKPSLGH LPPIQVCSPS CLKDGKDMKS TCTYLLLLLL LEFMVFFFFF 600
LTYSSVFGLH VKGLWTKICS DVQEYFSVS 629 
Gene Ontology
 GO:0016592; C:mediator complex; IDA:MGI.
 GO:0003682; F:chromatin binding; IDA:MGI.
 GO:0001047; F:core promoter binding; IDA:MGI.
 GO:0032403; F:protein complex binding; IDA:MGI.
 GO:0001104; F:RNA polymerase II transcription cofactor activity; IEA:InterPro.
 GO:0003713; F:transcription coactivator activity; IDA:MGI.
 GO:0007420; P:brain development; IMP:MGI.
 GO:0043010; P:camera-type eye development; IMP:MGI.
 GO:0035729; P:cellular response to hepatocyte growth factor stimulus; IMP:MGI.
 GO:0006260; P:DNA replication; IMP:MGI.
 GO:0035050; P:embryonic heart tube development; IMP:MGI.
 GO:0035162; P:embryonic hemopoiesis; IMP:MGI.
 GO:0035116; P:embryonic hindlimb morphogenesis; IMP:MGI.
 GO:0001892; P:embryonic placenta development; IMP:MGI.
 GO:0048822; P:enucleate erythrocyte development; IMP:MGI.
 GO:0060750; P:epithelial cell proliferation involved in mammary gland duct elongation; IMP:MGI.
 GO:0045444; P:fat cell differentiation; IMP:MGI.
 GO:0007595; P:lactation; IMP:MGI.
 GO:0001889; P:liver development; IMP:MGI.
 GO:0060745; P:mammary gland branching involved in pregnancy; IMP:MGI.
 GO:0060744; P:mammary gland branching involved in thelarche; IMP:MGI.
 GO:0030224; P:monocyte differentiation; IMP:MGI.
 GO:0031100; P:organ regeneration; IMP:MGI.
 GO:0035357; P:peroxisome proliferator activated receptor signaling pathway; IMP:MGI.
 GO:0070318; P:positive regulation of G0 to G1 transition; IMP:MGI.
 GO:2000347; P:positive regulation of hepatocyte proliferation; IMP:MGI.
 GO:0060335; P:positive regulation of interferon-gamma-mediated signaling pathway; IMP:MGI.
 GO:0033148; P:positive regulation of intracellular estrogen receptor signaling pathway; IMP:MGI.
 GO:0033601; P:positive regulation of mammary gland epithelial cell proliferation; IMP:MGI.
 GO:0033160; P:positive regulation of protein import into nucleus, translocation; IMP:MGI.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IDA:MGI.
 GO:0070562; P:regulation of vitamin D receptor signaling pathway; IMP:MGI.
 GO:0006590; P:thyroid hormone generation; IMP:MGI.
 GO:0006366; P:transcription from RNA polymerase II promoter; IC:MGI. 
Interpro
 IPR019680; Mediator_Med1_met/fun. 
Pfam
 PF10744; Med1 
SMART
  
PROSITE
  
PRINTS