CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019034
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Isochorismatase domain-containing protein 2, mitochondrial 
Protein Synonyms/Alias
  
Gene Name
 ISOC2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
26FLCDMQEKFRHNIAYubiquitination[1]
182PQFKEIQKLIKEPAPacetylation[2, 3]
185KEIQKLIKEPAPDSGacetylation[4]
185KEIQKLIKEPAPDSGubiquitination[5, 6]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861]
 [3] Proteomic investigations reveal a role for RNA processing factor THRAP3 in the DNA damage response.
 Beli P, Lukashchuk N, Wagner SA, Weinert BT, Olsen JV, Baskcomb L, Mann M, Jackson SP, Choudhary C.
 Mol Cell. 2012 Apr 27;46(2):212-25. [PMID: 22424773]
 [4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [5] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [6] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
  
Sequence Annotation
 MOD_RES 182 182 N6-acetyllysine.  
Keyword
 Acetylation; Alternative splicing; Complete proteome; Cytoplasm; Mitochondrion; Nucleus; Reference proteome; Transit peptide. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 205 AA 
Protein Sequence
MAAARPSLGR VLPGSSVLFL CDMQEKFRHN IAYFPQIVSV AARMLKVARL LEVPVMLTEQ 60
YPQGLGPTVP ELGTEGLRPL AKTCFSMVPA LQQELDSRPQ LRSVLLCGIE AQACILNTTL 120
DLLDRGLQVH VVVDACSSRS QVDRLVALAR MRQSGAFLST SEGLILQLVG DAVHPQFKEI 180
QKLIKEPAPD SGLLGLFQGQ NSLLH 205 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:BHF-UCL.
 GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IDA:BHF-UCL.
 GO:0003824; F:catalytic activity; IEA:InterPro.
 GO:0031648; P:protein destabilization; IMP:BHF-UCL. 
Interpro
 IPR000868; Isochorismatase-like. 
Pfam
 PF00857; Isochorismatase 
SMART
  
PROSITE
  
PRINTS