| Tag | Content |
|---|
| CPLM ID | CPLM-011725 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Pyruvate dehydrogenase E1 component |
Protein Synonyms/Alias | PDH E1 component |
Gene Name | aceE |
Gene Synonyms/Alias | Rv2241; MT2301; MTCY427.22 |
Created Date | July 27, 2013 |
Organism | Mycobacterium tuberculosis |
NCBI Taxa ID | 1773 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 346 | FGRDPRTKALVENMS | pupylation | [1] |
|
Reference | [1] Prokaryotic ubiquitin-like protein (Pup) proteome of Mycobacterium tuberculosis [corrected] . Festa RA, McAllister F, Pearce MJ, Mintseris J, Burns KE, Gygi SP, Darwin KH. PLoS One. 2010 Jan 6;5(1):e8589. [ PMID: 20066036] |
Functional Description | Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). AceE has reductase activity with pyruvate but does not react with 2-oxoglutarate. |
Sequence Annotation | CROSSLNK 346 346 Isoglutamyl lysine isopeptide (Lys-Gln) |
Keyword | Complete proteome; Glycolysis; Isopeptide bond; Magnesium; Oxidoreductase; Pyruvate; Reference proteome; Thiamine pyrophosphate; Ubl conjugation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 901 AA |
Protein Sequence | MASYLPDIDP EETSEWLESF DTLLQRCGPS RARYLMLRLL ERAGEQRVAI PALTSTDYVN 60
TIPTELEPWF PGDEDVERRY RAWIRWNAAI MVHRAQRPGV GVGGHISTYA SSAALYEVGF 120
NHFFRGKSHP GGGDQVFIQG HASPGIYARA FLEGRLTAEQ LDGFRQEHSH VGGGLPSYPH 180
PRLMPDFWEF PTVSMGLGPL NAIYQARFNH YLHDRGIKDT SDQHVWCFLG DGEMDEPESR 240
GLAHVGALEG LDNLTFVINC NLQRLDGPVR GNGKIIQELE SFFRGAGWNV IKVVWGREWD 300
ALLHADRDGA LVNLMNTTPD GDYQTYKAND GGYVRDHFFG RDPRTKALVE NMSDQDIWNL 360
KRGGHDYRKV YAAYRAAVDH KGQPTVILAK TIKGYALGKH FEGRNATHQM KKLTLEDLKE 420
FRDTQRIPVS DAQLEENPYL PPYYHPGLNA PEIRYMLDRR RALGGFVPER RTKSKALTLP 480
GRDIYAPLKK GSGHQEVATT MATVRTFKEV LRDKQIGPRI VPIIPDEART FGMDSWFPSL 540
KIYNRNGQLY TAVDADLMLA YKESEVGQIL HEGINEAGSV GSFIAAGTSY ATHNEPMIPI 600
YIFYSMFGFQ RTGDSFWAAA DQMARGFVLG ATAGRTTLTG EGLQHADGHS LLLAATNPAV 660
VAYDPAFAYE IAYIVESGLA RMCGENPENI FFYITVYNEP YVQPPEPENF DPEGVLRGIY 720
RYHAATEQRT NKAQILASGV AMPAALRAAQ MLAAEWDVAA DVWSVTSWGE LNRDGVAIET 780
EKLRHPDRPA GVPYVTRALE NARGPVIAVS DWMRAVPEQI RPWVPGTYLT LGTDGFGFSD 840
TRPAARRYFN TDAESQVVAV LEALAGDGEI DPSVPVAAAR QYRIDDVAAA PEQTTDPGPG 900
A 901 |
Gene Ontology | GO:0005618; C:cell wall; IDA:MTBBASE. GO:0005576; C:extracellular region; IDA:MTBBASE. GO:0005886; C:plasma membrane; IDA:MTBBASE. GO:0045254; C:pyruvate dehydrogenase complex; IDA:MTBBASE. GO:0000287; F:magnesium ion binding; IDA:MTBBASE. GO:0004739; F:pyruvate dehydrogenase (acetyl-transferring) activity; IDA:MTBBASE. GO:0006096; P:glycolysis; IEA:UniProtKB-KW. |
Interpro | |
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SMART | |
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PRINTS | |