UniProt Accession

 SPSY_MOUSE; P97355; A2AC82; Q3TL65; Q3TUP0; Q3UDT8; Q8C7P4; Q9CT09; Q9R282 

Genbank Protein ID

 Y09419; AF031486; AK049787; AK011542; AK017775; AK149929; AK160637; AK160659; AK166665; AL663072; BC046623; BC058688; AF136179; AJ000093; AJ000087; AJ000088; AJ000089; AJ000090; AJ000091; AJ000092 

Genbank Nucleotide ID

 CAA70573.1; AAB86631.1; BAC33920.1; BAB27685.1; BAB30923.1; BAE29173.1; BAE35931.1; BAE35947.1; BAE38927.1; CAM18089.1; AAH46623.1; AAH58688.1; AAD33057.1; CAA03919.1; CAA03918.1; CAA03918.1; CAA03918.1; CAA03918.1; CAA03918.1; CAA03918.1 

Protein Name

 Spermine synthase 

Protein Synonyms/Alias

 SPMSY; Spermidine aminopropyltransferase 

Gene Name

 Sms 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
151	DSPYQNIKILHSKQF	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Catalyzes the production of spermine from spermidine and decarboxylated S-adenosylmethionine (dcSAM) (By similarity). Required for normal viability, growth and fertility. 

Sequence Annotation

 REGION 255 256 S-adenosylmethioninamine binding (By
 ACT_SITE 276 276 Proton acceptor (By similarity).
 BINDING 148 148 S-adenosylmethioninamine (By similarity).
 BINDING 177 177 Spermidine (By similarity).
 BINDING 201 201 Spermidine (By similarity).
 BINDING 220 220 S-adenosylmethioninamine (By similarity).
 BINDING 351 351 Spermidine (By similarity).
 BINDING 353 353 Spermidine (By similarity).
 MOD_RES 2 2 N-acetylalanine (By similarity).  

Keyword

 Acetylation; Complete proteome; Direct protein sequencing; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 366 AA 

Protein Sequence

Gene Ontology

 GO:0016768; F:spermine synthase activity; IEA:EC.
 GO:0006597; P:spermine biosynthetic process; IEA:UniProtKB-UniPathway. 

Interpro

 IPR001045; Spermidine/spermine_synthase.
 IPR015576; Spermine_synthase. 

Pfam

 PF01564; Spermine_synth 

SMART

  

PROSITE

 PS01330; SPERMIDINE_SYNTHASE_1
 PS51006; SPERMIDINE_SYNTHASE_2 

PRINTS