CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-004598
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Erythroid transcription factor 
Protein Synonyms/Alias
 Eryf1; GATA-binding factor 1; GATA-1; GF-1; NF-E1 DNA-binding protein 
Gene Name
 Gata1 
Gene Synonyms/Alias
 Gf-1 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
233NACGLYHKMNGQNRPacetylation[1]
245NRPLIRPKKRMIVSKacetylation[1]
246RPLIRPKKRMIVSKRacetylation[1]
252KKRMIVSKRAGTQCTacetylation[1]
287NACGLYFKLHQVNRPacetylation[1]
299NRPLTMRKDGIQTRNacetylation[1]
308GIQTRNRKASGKGKKacetylation[1]
312RNRKASGKGKKKRGSacetylation[1]
314RKASGKGKKKRGSNLacetylation[1]
315KASGKGKKKRGSNLAacetylation[1]
316ASGKGKKKRGSNLAGacetylation[1]
Reference
 [1] CREB-Binding protein acetylates hematopoietic transcription factor GATA-1 at functionally important sites.
 Hung HL, Lau J, Kim AY, Weiss MJ, Blobel GA.
 Mol Cell Biol. 1999 May;19(5):3496-505. [PMID: 10207073] 
Functional Description
 Transcriptional activator which probably serves as a general switch factor for erythroid development. It binds to DNA sites with the consensus sequence [AT]GATA[AG] within regulatory regions of globin genes and of other genes expressed in erythroid cells. 
Sequence Annotation
 ZN_FING 204 228 GATA-type 1.
 ZN_FING 258 282 GATA-type 2.
 REGION 203 222 Required for interaction with ZFPM1 (By
 MOD_RES 26 26 Phosphoserine.
 MOD_RES 49 49 Phosphoserine.
 MOD_RES 72 72 Phosphoserine.
 MOD_RES 142 142 Phosphoserine.
 MOD_RES 178 178 Phosphoserine.
 MOD_RES 187 187 Phosphoserine.
 MOD_RES 233 233 N6-acetyllysine; by EP300 (By
 MOD_RES 245 245 N6-acetyllysine; by EP300 (By
 MOD_RES 246 246 N6-acetyllysine; by CREBBP.
 MOD_RES 246 246 N6-acetyllysine; by EP300 (By
 MOD_RES 252 252 N6-acetyllysine; by CREBBP.
 MOD_RES 308 308 N6-acetyllysine.
 MOD_RES 310 310 Phosphoserine.
 MOD_RES 312 312 N6-acetyllysine; by CREBBP.
 MOD_RES 314 314 N6-acetyllysine.
 MOD_RES 315 315 N6-acetyllysine.
 CROSSLNK 137 137 Glycyl lysine isopeptide (Lys-Gly)  
Keyword
 3D-structure; Acetylation; Activator; Alternative initiation; Complete proteome; Direct protein sequencing; DNA-binding; Isopeptide bond; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; Transcription; Transcription regulation; Ubl conjugation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 413 AA 
Protein Sequence
MDFPGLGALG TSEPLPQFVD SALVSSPSDS TGFFSSGPEG LDAASSSTSP NAATAAASAL 60
AYYREAEAYR HSPVFQVYPL LNSMEGIPGG SPYASWAYGK TALYPASTVC PSHEDAPSQA 120
LEDQEGKSNN TFLDTLKTER LSPDLLTLGT ALPASLPVTG SAYGGADFPS PFFSPTGSPL 180
SSAAYSSPKF HGSLPLAPCE ARECVNCGAT ATPLWRRDRT GHYLCNACGL YHKMNGQNRP 240
LIRPKKRMIV SKRAGTQCTN CQTTTTTLWR RNASGDPVCN ACGLYFKLHQ VNRPLTMRKD 300
GIQTRNRKAS GKGKKKRGSN LAGAGAAEGP AGGFMVVAGS SSSGNCGEVA SGLALGTAGT 360
AHLYQGLGPV VLSGPVSHLM PFPGPLLGSP TTSFPTGPAP TTSSTSVIAP LSS 413 
Gene Ontology
 GO:0031965; C:nuclear membrane; IEA:Compara.
 GO:0005730; C:nucleolus; IEA:Compara.
 GO:0005634; C:nucleus; IDA:MGI.
 GO:0005667; C:transcription factor complex; IEA:Compara.
 GO:0017053; C:transcriptional repressor complex; IEA:Compara.
 GO:0003682; F:chromatin binding; IDA:MGI.
 GO:0008301; F:DNA binding, bending; IDA:MGI.
 GO:0001158; F:enhancer sequence-specific DNA binding; IDA:UniProtKB.
 GO:0000978; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding; IDA:MGI.
 GO:0001078; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; IEA:Compara.
 GO:0001077; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription; IDA:MGI.
 GO:0043565; F:sequence-specific DNA binding; IDA:MGI.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0030221; P:basophil differentiation; IEA:Compara.
 GO:0007267; P:cell-cell signaling; IMP:MGI.
 GO:0097067; P:cellular response to thyroid hormone stimulus; IEA:Compara.
 GO:0097028; P:dendritic cell differentiation; IDA:MGI.
 GO:0035162; P:embryonic hemopoiesis; IMP:MGI.
 GO:0035854; P:eosinophil fate commitment; IEA:Compara.
 GO:0048821; P:erythrocyte development; IEA:Compara.
 GO:0030218; P:erythrocyte differentiation; IDA:MGI.
 GO:0001701; P:in utero embryonic development; IMP:MGI.
 GO:0008584; P:male gonad development; IEA:Compara.
 GO:0030219; P:megakaryocyte differentiation; IDA:MGI.
 GO:0043066; P:negative regulation of apoptotic process; IMP:MGI.
 GO:0030502; P:negative regulation of bone mineralization; IMP:MGI.
 GO:0008285; P:negative regulation of cell proliferation; IMP:MGI.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IDA:MGI.
 GO:2000678; P:negative regulation of transcription regulatory region DNA binding; IEA:Compara.
 GO:0070527; P:platelet aggregation; IMP:BHF-UCL.
 GO:0030220; P:platelet formation; IEA:Compara.
 GO:0045648; P:positive regulation of erythrocyte differentiation; IEA:Compara.
 GO:0033690; P:positive regulation of osteoblast proliferation; IMP:MGI.
 GO:0050731; P:positive regulation of peptidyl-tyrosine phosphorylation; IMP:BHF-UCL.
 GO:0010724; P:regulation of definitive erythrocyte differentiation; IDA:BHF-UCL.
 GO:0010559; P:regulation of glycoprotein biosynthetic process; IMP:BHF-UCL.
 GO:0071733; P:transcriptional activation by promoter-enhancer looping; IDA:BHF-UCL. 
Interpro
 IPR016374; TF_GATA-1/2/3.
 IPR000679; Znf_GATA.
 IPR013088; Znf_NHR/GATA. 
Pfam
 PF00320; GATA 
SMART
 SM00401; ZnF_GATA 
PROSITE
 PS00344; GATA_ZN_FINGER_1
 PS50114; GATA_ZN_FINGER_2 
PRINTS
 PR00619; GATAZNFINGER.