UniProt Accession

 RB27B_RAT; Q99P74 

Genbank Protein ID

 AF325693 

Genbank Nucleotide ID

 AAG49587.1 

Protein Name

 Ras-related protein Rab-27B 

Protein Synonyms/Alias

  

Gene Name

 Rab27b 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
154	QARELAEKYGIPYFE	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 May be involved in targeting uroplakins to urothelial apical membranes (By similarity). 

Sequence Annotation

 NP_BIND 16 24 GTP (By similarity).
 NP_BIND 74 78 GTP (By similarity).
 NP_BIND 133 136 GTP (By similarity).
 NP_BIND 163 165 GTP (By similarity).
 MOTIF 38 46 Effector region (By similarity).
 MOD_RES 2 2 N-acetylthreonine (By similarity).
 MOD_RES 218 218 Cysteine methyl ester (By similarity).
 LIPID 216 216 S-geranylgeranyl cysteine (By
 LIPID 218 218 S-geranylgeranyl cysteine (By
 DISULFID 123 188 By similarity.  

Keyword

 Acetylation; Complete proteome; Disulfide bond; GTP-binding; Lipoprotein; Membrane; Methylation; Nucleotide-binding; Prenylation; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 218 AA 

Protein Sequence

Gene Ontology

 GO:0016324; C:apical plasma membrane; IDA:RGD.
 GO:0005795; C:Golgi stack; IEA:Compara.
 GO:0032585; C:multivesicular body membrane; IEA:Compara.
 GO:0030140; C:trans-Golgi network transport vesicle; IEA:Compara.
 GO:0042589; C:zymogen granule membrane; IDA:RGD.
 GO:0019003; F:GDP binding; ISS:UniProtKB.
 GO:0005525; F:GTP binding; ISS:UniProtKB.
 GO:0003924; F:GTPase activity; ISS:UniProtKB.
 GO:0071985; P:multivesicular body sorting pathway; IEA:Compara.
 GO:0045921; P:positive regulation of exocytosis; IEA:Compara.
 GO:0015031; P:protein transport; IEA:InterPro.
 GO:0017157; P:regulation of exocytosis; IDA:RGD.
 GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR005225; Small_GTP-bd_dom.
 IPR001806; Small_GTPase.
 IPR003579; Small_GTPase_Rab_type. 

Pfam

 PF00071; Ras 

SMART

 SM00175; RAB 

PROSITE

 PS51419; RAB 

PRINTS

 PR00449; RASTRNSFRMNG.