CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-026199
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 E3 ubiquitin/ISG15 ligase TRIM25 
Protein Synonyms/Alias
  
Gene Name
 Trim25 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
200ASADLEYKLRNKLTIubiquitination[1]
225ALEDVRSKQQCVQDSubiquitination[1]
234QCVQDSMKRKMEQLRubiquitination[1]
282TIYQVLVKKKSEMQKubiquitination[1]
309DEFEFLEKAAKLQGEubiquitination[1]
312EFLEKAAKLQGESTKubiquitination[1]
319KLQGESTKPVYIPKIubiquitination[1]
376DQTQSTFKPVQPSKKubiquitination[1]
382FKPVQPSKKTIPVAPubiquitination[1]
422TSPDAAPKASAAQPDubiquitination[1]
434QPDSVGVKAKVLENFubiquitination[1]
436DSVGVKAKVLENFLTubiquitination[1]
472NKVSLSNKYTTASVSubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Metal-binding; Reference proteome; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 626 AA 
Protein Sequence
MAELNPLAEE LSCSVCLELF KEPVTTPCGH NFCMSCLDET WVVQGPPYRC PQCRKVYQVR 60
PQLQKNTVMC AVVEQFLQAE QARTPVDDWT PPARFSASSA ATQVACDHCL TEIAVKTCLV 120
CMASFCQEHL RPHFDSPAFQ DHPLQSPIRD LLRRKCTQHN RLRELFCPEH GECICHICLV 180
EHKTCSPTTL SQASADLEYK LRNKLTIMHS HINGATKALE DVRSKQQCVQ DSMKRKMEQL 240
RQEYMEMKAV IDAAETSSLR KLKEEEKRVY GKFDTIYQVL VKKKSEMQKL KAEVELIMDK 300
GDEFEFLEKA AKLQGESTKP VYIPKIDLDH DLIMGIYQGA ADLKSELKHS IKKLQKKSEE 360
HNGSGNKGDQ TQSTFKPVQP SKKTIPVAPG PPSHFSPNKL PTFGAPGQSL DSKATSPDAA 420
PKASAAQPDS VGVKAKVLEN FLTKSRTELL EYFVKVIFDY NTAHNKVSLS NKYTTASVSD 480
GLQHYRSHPQ RFTYCSQVLG LHCYKNGIHY WEVELQKNNF CGVGICYGSM ERQGPESRLG 540
RNPNSWCVEW FNNKISAWHN NVEKTLPSTK ATRVGVLLNC DHGFVIFFAV TEKVHLMYKF 600
KVDFTEALYP AFWVFSAGTT LSICSK 626 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0008270; F:zinc ion binding; IEA:InterPro. 
Interpro
 IPR001870; B30.2/SPRY.
 IPR003879; Butyrophylin.
 IPR008985; ConA-like_lec_gl_sf.
 IPR006574; PRY.
 IPR018355; SPla/RYanodine_receptor_subgr.
 IPR003877; SPRY_rcpt.
 IPR001841; Znf_RING.
 IPR013083; Znf_RING/FYVE/PHD.
 IPR017907; Znf_RING_CS. 
Pfam
 PF00622; SPRY 
SMART
 SM00589; PRY
 SM00184; RING
 SM00449; SPRY 
PROSITE
 PS50188; B302_SPRY
 PS00518; ZF_RING_1
 PS50089; ZF_RING_2 
PRINTS
 PR01407; BUTYPHLNCDUF.