UniProt Accession

 DCK_MOUSE; P43346 

Genbank Protein ID

 X77731; AF260315; BC060062 

Genbank Nucleotide ID

 CAA54787.1; AAG53743.1; AAH60062.1 

Protein Name

 Deoxycytidine kinase 

Protein Synonyms/Alias

 dCK 

Gene Name

 Dck 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
117	ASLNGKLKDAEKPVL	ubiquitination	[1]
121	GKLKDAEKPVLFFER	ubiquitination	[1]

Reference

 [1] BTB-ZF factors recruit the E3 ligase cullin 3 to regulate lymphoid effector programs.
 Mathew R, Seiler MP, Scanlon ST, Mao AP, Constantinides MG, Bertozzi-Villa C, Singer JD, Bendelac A.
 Nature. 2012 Nov 22;491(7425):618-21. [PMID: 23086144] 

Functional Description

 Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). 

Sequence Annotation

 NP_BIND 28 36 ATP (By similarity).
 NP_BIND 188 192 ATP (By similarity).
 NP_BIND 240 242 ATP (By similarity).
 ACT_SITE 127 127 Proton acceptor (Potential).
 BINDING 53 53 Substrate (By similarity).
 BINDING 86 86 Substrate (By similarity).
 BINDING 97 97 Substrate (By similarity).
 BINDING 128 128 Substrate (By similarity).
 BINDING 133 133 Substrate (By similarity).
 BINDING 197 197 Substrate (By similarity).
 MOD_RES 11 11 Phosphoserine; by CK1 (By similarity).
 MOD_RES 15 15 Phosphoserine; by CK1 (By similarity).
 MOD_RES 72 72 Phosphothreonine; by CK1 (By similarity).
 MOD_RES 74 74 Phosphoserine; by CK1 (By similarity).  

Keyword

 ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 260 AA 

Protein Sequence

Gene Ontology

 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0004137; F:deoxycytidine kinase activity; ISS:UniProtKB.
 GO:0008144; F:drug binding; IEA:Compara.
 GO:0016773; F:phosphotransferase activity, alcohol group as acceptor; IEA:InterPro.
 GO:0006220; P:pyrimidine nucleotide metabolic process; ISS:UniProtKB. 

Interpro

 IPR002624; Deoxynucleoside_kinase.
 IPR027417; P-loop_NTPase. 

Pfam

 PF01712; dNK 

SMART

  

PROSITE

  

PRINTS