UniProt Accession

 B4DWI1_HUMAN; B4DWI1 

Genbank Protein ID

 AC027129; AK301546 

Genbank Nucleotide ID

 BAG63043.1 

Protein Name

 2-hydroxyacyl-CoA lyase 1 

Protein Synonyms/Alias

 cDNA FLJ53672, highly similar to 2-hydroxyphytanoyl-CoA lyase (EC 4.1.-.-) 

Gene Name

 HACL1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
109	EACRLYTKFSARPSS	ubiquitination	[1]
126	AIPFVIEKAVRSSIY	ubiquitination	[1, 2, 3]
187	ASVIRNAKQPLLIIG	ubiquitination	[1, 2]
214	KKLVEQYKLPFLPTP	ubiquitination	[1, 2]
224	FLPTPMGKGVVPDNH	ubiquitination	[1]

Reference

 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Lyase; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 551 AA 

Protein Sequence

Gene Ontology

 GO:0016829; F:lyase activity; IEA:UniProtKB-KW.
 GO:0000287; F:magnesium ion binding; IEA:InterPro.
 GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
 GO:0008152; P:metabolic process; IEA:GOC. 

Interpro

 IPR012000; Thiamin_PyroP_enz_cen_dom.
 IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
 IPR011766; TPP_enzyme-bd_C. 

Pfam

 PF02775; TPP_enzyme_C
 PF00205; TPP_enzyme_M
 PF02776; TPP_enzyme_N 

SMART

  

PROSITE

  

PRINTS