UniProt Accession

 KTHY_MOUSE; P97930; Q8C2L0; Q8K2S2 

Genbank Protein ID

 S82852; S82853; AK088416; BC030178 

Genbank Nucleotide ID

 AAB46837.1; AAB46838.1; BAC40343.1; AAH30178.1 

Protein Name

 Thymidylate kinase 

Protein Synonyms/Alias

 dTMP kinase 

Gene Name

 Dtymk 

Gene Synonyms/Alias

 Tmk 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
51	ERSTEIGKLLNSYLE	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Catalyzes the conversion of dTMP to dTDP. 

Sequence Annotation

 NP_BIND 13 20 ATP (By similarity).
 MOD_RES 2 2 N-acetylalanine (By similarity).  

Keyword

 Acetylation; Alternative splicing; ATP-binding; Complete proteome; Kinase; Nucleotide biosynthesis; Nucleotide-binding; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 212 AA 

Protein Sequence

Gene Ontology

 GO:0005758; C:mitochondrial intermembrane space; IEA:Compara.
 GO:0005759; C:mitochondrial matrix; IEA:Compara.
 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0050145; F:nucleoside phosphate kinase activity; IEA:Compara.
 GO:0004798; F:thymidylate kinase activity; IDA:MGI.
 GO:0071363; P:cellular response to growth factor stimulus; IDA:MGI.
 GO:0006233; P:dTDP biosynthetic process; IDA:MGI.
 GO:0006235; P:dTTP biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0045445; P:myoblast differentiation; IEA:Compara.
 GO:0046686; P:response to cadmium ion; IEA:Compara.
 GO:0043627; P:response to estrogen stimulus; IEA:Compara. 

Interpro

 IPR027417; P-loop_NTPase.
 IPR018095; Thymidylate_kin_CS.
 IPR018094; Thymidylate_kinase. 

Pfam

  

SMART

  

PROSITE

 PS01331; THYMIDYLATE_KINASE 

PRINTS