UniProt Accession

 NDK_ECOLI; P0A763; P24233 

Genbank Protein ID

 X57555; U00096; AP009048 

Genbank Nucleotide ID

 CAA40780.1; AAC75571.1; BAA16405.1 

Protein Name

 Nucleoside diphosphate kinase 

Protein Synonyms/Alias

 NDK; NDP kinase; Nucleoside-2-P kinase 

Gene Name

 ndk 

Gene Synonyms/Alias

 b2518; JW2502 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
11	ERTFSIIKPNAVAKN	acetylation	[1]
17	IKPNAVAKNVIGNIF	acetylation	[1]
33	RFEAAGFKIVGTKML	acetylation	[1]
38	GFKIVGTKMLHLTVE	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. 

Sequence Annotation

 ACT_SITE 117 117 Pros-phosphohistidine intermediate.
 BINDING 11 11 ATP (By similarity).
 BINDING 59 59 ATP (By similarity).
 BINDING 87 87 ATP (By similarity).
 BINDING 93 93 ATP (By similarity).
 BINDING 104 104 ATP (By similarity).
 BINDING 114 114 ATP (By similarity).
 MOD_RES 119 119 Phosphoserine.
 MOD_RES 121 121 Phosphoserine.  

Keyword

 3D-structure; ATP-binding; Complete proteome; Cytoplasm; Direct protein sequencing; Kinase; Magnesium; Metal-binding; Nucleotide metabolism; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 143 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0005524; F:ATP binding; IEA:HAMAP.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0004550; F:nucleoside diphosphate kinase activity; IDA:EcoCyc.
 GO:0006241; P:CTP biosynthetic process; IEA:HAMAP.
 GO:0006183; P:GTP biosynthetic process; IEA:HAMAP.
 GO:0006228; P:UTP biosynthetic process; IEA:HAMAP. 

Interpro

 IPR001564; Nucleoside_diP_kinase.
 IPR023005; Nucleoside_diP_kinase_AS. 

Pfam

 PF00334; NDK 

SMART

 SM00562; NDK 

PROSITE

 PS00469; NDP_KINASES 

PRINTS

 PR01243; NUCDPKINASE.