UniProt Accession

 B1AMX8_HUMAN; B1AMX8 

Genbank Protein ID

 AL355987; AL449425 

Genbank Nucleotide ID

  

Protein Name

 TRAF family member-associated NF-kappa-B activator 

Protein Synonyms/Alias

  

Gene Name

 TRAF2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
176	PCCGADVKAHHEVCP	ubiquitination	[1, 2, 3]

Reference

 [1] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [2] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [3] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302] 

Functional Description

  

Sequence Annotation

  

Keyword

 Complete proteome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 193 AA 

Protein Sequence

Gene Ontology

 GO:0035631; C:CD40 receptor complex; IEA:Compara.
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0009898; C:internal side of plasma membrane; IEA:Compara.
 GO:0004842; F:ubiquitin-protein ligase activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0007250; P:activation of NF-kappaB-inducing kinase activity; IEA:InterPro.
 GO:0043623; P:cellular protein complex assembly; IEA:Compara.
 GO:0051865; P:protein autoubiquitination; IEA:InterPro.
 GO:0030163; P:protein catabolic process; IEA:Compara.
 GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
 GO:0051023; P:regulation of immunoglobulin secretion; IEA:Compara.
 GO:0046328; P:regulation of JNK cascade; IEA:Compara.
 GO:0033209; P:tumor necrosis factor-mediated signaling pathway; IEA:InterPro. 

Interpro

 IPR027133; TRAF2.
 IPR018957; Znf_C3HC4_RING-type.
 IPR001841; Znf_RING.
 IPR013083; Znf_RING/FYVE/PHD.
 IPR017907; Znf_RING_CS.
 IPR001293; Znf_TRAF. 

Pfam

 PF00097; zf-C3HC4 

SMART

 SM00184; RING 

PROSITE

 PS00518; ZF_RING_1
 PS50089; ZF_RING_2
 PS50145; ZF_TRAF 

PRINTS