UniProt Accession

 PA1B2_RAT; O35264 

Genbank Protein ID

 AF016048; BC081714 

Genbank Nucleotide ID

 AAC27974.1; AAH81714.1 

Protein Name

 Platelet-activating factor acetylhydrolase IB subunit beta 

Protein Synonyms/Alias

 PAF acetylhydrolase 30 kDa subunit; PAF-AH 30 kDa subunit; PAF-AH subunit beta; PAFAH subunit beta; Platelet-activating factor acetylhydrolase alpha 2 subunit; PAF-AH alpha 2 

Gene Name

 Pafah1b2 

Gene Synonyms/Alias

 Pafahb 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
145	GLLPRGEKPNPLRQK	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Inactivates PAF by removing the acetyl group at the sn-2 position. This is a catalytic subunit. 

Sequence Annotation

 ACT_SITE 48 48 By similarity.
 ACT_SITE 193 193 By similarity.
 ACT_SITE 196 196 By similarity.
 MOD_RES 2 2 N-acetylserine (By similarity).
 MOD_RES 2 2 Phosphoserine (By similarity).  

Keyword

 Acetylation; Complete proteome; Cytoplasm; Direct protein sequencing; Hydrolase; Lipid degradation; Lipid metabolism; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 229 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:RGD.
 GO:0005730; C:nucleolus; IEA:Compara.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0003847; F:1-alkyl-2-acetylglycerophosphocholine esterase activity; IEA:EC.
 GO:0047179; F:platelet-activating factor acetyltransferase activity; IDA:RGD.
 GO:0042803; F:protein homodimerization activity; IDA:RGD.
 GO:0007420; P:brain development; IEP:RGD.
 GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
 GO:0016239; P:positive regulation of macroautophagy; IEA:Compara.
 GO:0007283; P:spermatogenesis; IEA:Compara. 

Interpro

 IPR013831; SGNH_hydro-type_esterase_dom. 

Pfam

  

SMART

  

PROSITE

 PS01098; LIPASE_GDSL_SER 

PRINTS