CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-028453
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 14-3-3 protein beta/alpha 
Protein Synonyms/Alias
  
Gene Name
 Ywhab 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
5***MTMDKSELVQKAacetylation[1]
11DKSELVQKAKLAEQAubiquitination[2]
13SELVQKAKLAEQAERacetylation[1, 3]
13SELVQKAKLAEQAERubiquitination[2]
29DDMAAAMKAVTEQGHubiquitination[2]
51NLLSVAYKNVVGARRacetylation[1, 3, 4]
51NLLSVAYKNVVGARRphosphoglycerylation[5]
51NLLSVAYKNVVGARRubiquitination[2]
70VISSIEQKTERNEKKacetylation[1]
70VISSIEQKTERNEKKubiquitination[2]
122ESKVFYLKMKGDYFRacetylation[1, 6]
122ESKVFYLKMKGDYFRubiquitination[2]
124KVFYLKMKGDYFRYLacetylation[1]
124KVFYLKMKGDYFRYLubiquitination[2]
140EVASGENKQTTVSNSubiquitination[2]
Reference
 [1] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [4] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [5] Functional lysine modification by an intrinsically reactive primary glycolytic metabolite.
 Moellering RE, Cravatt BF.
 Science. 2013 Aug 2;341(6145):549-53. [PMID: 23908237]
 [6] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 159 AA 
Protein Sequence
MTMDKSELVQ KAKLAEQAER YDDMAAAMKA VTEQGHELSN EERNLLSVAY KNVVGARRSS 60
WRVISSIEQK TERNEKKQQM GKEYREKIEA ELQDICNDVL ELLDKYLILN ATQAESKVFY 120
LKMKGDYFRY LSEVASGENK QTTVSNSQQA YQEAFEISK 159 
Gene Ontology
 GO:0048471; C:perinuclear region of cytoplasm; IEA:Compara.
 GO:0017053; C:transcriptional repressor complex; IEA:Compara.
 GO:0019904; F:protein domain specific binding; IDA:MGI.
 GO:0003714; F:transcription corepressor activity; IEA:Compara.
 GO:0051220; P:cytoplasmic sequestering of protein; IEA:Compara.
 GO:0035308; P:negative regulation of protein dephosphorylation; IEA:Compara.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; IEA:Compara.
 GO:0043085; P:positive regulation of catalytic activity; IEA:Compara.
 GO:0051291; P:protein heterooligomerization; IEA:Compara.
 GO:0006605; P:protein targeting; IDA:MGI. 
Interpro
 IPR000308; 14-3-3.
 IPR023409; 14-3-3_CS.
 IPR023410; 14-3-3_domain. 
Pfam
 PF00244; 14-3-3 
SMART
 SM00101; 14_3_3 
PROSITE
 PS00796; 1433_1 
PRINTS
 PR00305; 1433ZETA.