CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-012397
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Metabotropic glutamate receptor 7 
Protein Synonyms/Alias
 mGluR7 
Gene Name
 GRM7 
Gene Synonyms/Alias
 GPRC1G; MGLUR7 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
889DRPNGEAKTELCENVsumoylation[1, 2]
Reference
 [1] Analysis of metabotropic glutamate receptor 7 as a potential substrate for SUMOylation.
 Wilkinson KA, Henley JM.
 Neurosci Lett. 2011 Mar 24;491(3):181-6. [PMID: 21255632]
 [2] Human Polycomb protein 2 promotes α-synuclein aggregate formation through covalent SUMOylation.
 Oh Y, Kim YM, Mouradian MM, Chung KC.
 Brain Res. 2011 Mar 24;1381:78-89. [PMID: 21256122] 
Functional Description
 Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. 
Sequence Annotation
 CARBOHYD 98 98 N-linked (GlcNAc...) (Potential).
 CARBOHYD 458 458 N-linked (GlcNAc...) (Potential).
 CARBOHYD 486 486 N-linked (GlcNAc...) (Potential).
 CARBOHYD 572 572 N-linked (GlcNAc...) (Potential).
 DISULFID 67 109 By similarity.
 DISULFID 249 541 By similarity.
 DISULFID 374 390 By similarity.
 DISULFID 430 437 By similarity.
 DISULFID 523 542 By similarity.
 DISULFID 527 545 By similarity.
 DISULFID 548 560 By similarity.
 DISULFID 563 576 By similarity.  
Keyword
 3D-structure; Alternative splicing; Cell membrane; Complete proteome; Disulfide bond; G-protein coupled receptor; Glycoprotein; Membrane; Olfaction; Polymorphism; Receptor; Reference proteome; Sensory transduction; Signal; Transducer; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 915 AA 
Protein Sequence
MVQLRKLLRV LTLMKFPCCV LEVLLCALAA AARGQEMYAP HSIRIEGDVT LGGLFPVHAK 60
GPSGVPCGDI KRENGIHRLE AMLYALDQIN SDPNLLPNVT LGARILDTCS RDTYALEQSL 120
TFVQALIQKD TSDVRCTNGE PPVFVKPEKV VGVIGASGSS VSIMVANILR LFQIPQISYA 180
STAPELSDDR RYDFFSRVVP PDSFQAQAMV DIVKALGWNY VSTLASEGSY GEKGVESFTQ 240
ISKEAGGLCI AQSVRIPQER KDRTIDFDRI IKQLLDTPNS RAVVIFANDE DIKQILAAAK 300
RADQVGHFLW VGSDSWGSKI NPLHQHEDIA EGAITIQPKR ATVEGFDAYF TSRTLENNRR 360
NVWFAEYWEE NFNCKLTISG SKKEDTDRKC TGQERIGKDS NYEQEGKVQF VIDAVYAMAH 420
ALHHMNKDLC ADYRGVCPEM EQAGGKKLLK YIRNVNFNGS AGTPVMFNKN GDAPGRYDIF 480
QYQTTNTSNP GYRLIGQWTD ELQLNIEDMQ WGKGVREIPA SVCTLPCKPG QRKKTQKGTP 540
CCWTCEPCDG YQYQFDEMTC QHCPYDQRPN ENRTGCQDIP IIKLEWHSPW AVIPVFLAML 600
GIIATIFVMA TFIRYNDTPI VRASGRELSY VLLTGIFLCY IITFLMIAKP DVAVCSFRRV 660
FLGLGMCISY AALLTKTNRI YRIFEQGKKS VTAPRLISPT SQLAITSSLI SVQLLGVFIW 720
FGVDPPNIII DYDEHKTMNP EQARGVLKCD ITDLQIICSL GYSILLMVTC TVYAIKTRGV 780
PENFNEAKPI GFTMYTTCIV WLAFIPIFFG TAQSAEKLYI QTTTLTISMN LSASVALGML 840
YMPKVYIIIF HPELNVQKRK RSFKAVVTAA TMSSRLSHKP SDRPNGEAKT ELCENVDPNS 900
PAAKKKYVSY NNLVI 915 
Gene Ontology
 GO:0032279; C:asymmetric synapse; ISS:UniProtKB.
 GO:0030424; C:axon; ISS:UniProtKB.
 GO:0005938; C:cell cortex; IDA:UniProtKB.
 GO:0043198; C:dendritic shaft; ISS:UniProtKB.
 GO:0005887; C:integral to plasma membrane; NAS:UniProtKB.
 GO:0045211; C:postsynaptic membrane; ISS:UniProtKB.
 GO:0048786; C:presynaptic active zone; ISS:UniProtKB.
 GO:0042734; C:presynaptic membrane; IEA:Compara.
 GO:0010855; F:adenylate cyclase inhibitor activity; IDA:UniProtKB.
 GO:0005246; F:calcium channel regulator activity; IEA:Compara.
 GO:0005509; F:calcium ion binding; IDA:UniProtKB.
 GO:0016595; F:glutamate binding; IDA:UniProtKB.
 GO:0001642; F:group III metabotropic glutamate receptor activity; IDA:UniProtKB.
 GO:0030165; F:PDZ domain binding; NAS:UniProtKB.
 GO:0070905; F:serine binding; IDA:UniProtKB.
 GO:0005245; F:voltage-gated calcium channel activity; IEA:Compara.
 GO:0030534; P:adult behavior; IEA:Compara.
 GO:0001661; P:conditioned taste aversion; IEA:Compara.
 GO:0033555; P:multicellular organismal response to stress; IEA:Compara.
 GO:0007194; P:negative regulation of adenylate cyclase activity; IDA:UniProtKB.
 GO:0014050; P:negative regulation of glutamate secretion; ISS:UniProtKB.
 GO:0007608; P:sensory perception of smell; IEA:UniProtKB-KW.
 GO:0007605; P:sensory perception of sound; IMP:UniProtKB.
 GO:0007614; P:short-term memory; IEA:Compara.
 GO:0007268; P:synaptic transmission; IDA:UniProtKB. 
Interpro
 IPR001828; ANF_lig-bd_rcpt.
 IPR000337; GPCR_3.
 IPR011500; GPCR_3_9-Cys_dom.
 IPR017978; GPCR_3_C.
 IPR017979; GPCR_3_CS.
 IPR000162; GPCR_3_mtglu_rcpt.
 IPR001883; GPCR_3_mtglu_rcpt_7. 
Pfam
 PF00003; 7tm_3
 PF01094; ANF_receptor
 PF07562; NCD3G 
SMART
  
PROSITE
 PS00979; G_PROTEIN_RECEP_F3_1
 PS00980; G_PROTEIN_RECEP_F3_2
 PS00981; G_PROTEIN_RECEP_F3_3
 PS50259; G_PROTEIN_RECEP_F3_4 
PRINTS
 PR00248; GPCRMGR.
 PR01057; MTABOTROPC7R.
 PR00593; MTABOTROPICR.