CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038192
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Disintegrin and metalloproteinase domain-containing protein 17 
Protein Synonyms/Alias
  
Gene Name
 Adam17 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
747SASVRIIKPFPAPQTubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Disulfide bond; Hydrolase; Metal-binding; Metalloprotease; Protease; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 846 AA 
Protein Sequence
MRRRLLILTT LVPFVLAPRP PEEAGSGSHP RLEKLDSLLS DYDILSLANI QQHSIRKRDL 60
QSATHLETLL TFSALKRHFK LYLTSSTERF SQNLRVVVVD GKEESEYSVK WQNFFSGHVV 120
GEPDSRVLAH IGDDDVTVRI NTDGAEYNVE PLWRFVNDTK DKRMLVYKSE DIKDFSRLQS 180
PKVCGYLNAD SEELLPKGLI DREPSEEFVR RVKRRAEPNP LKNTCKLLVV ADHRFYKYMG 240
RGEESTTTNY LGYISGTRDR VTTDCFLEFL IELIDRVDDI YRNTSWDNAG FKGYGVQIEQ 300
IRILKSPQEV KPGERHFNMA KSFPNEEKDA WDVKMLLEQF SFDIAEEASK VCLAHLFTYQ 360
DFDMGTLGLA YVGSPRANSH GGVCPKAYYN PTVKKNIYLN SGLTSTKNYG KTILTKEADL 420
VTTHELGHNF GAEHDPDGLA ECAPNEDQGG KYVMYPIAVS GDHENNKMFS NCSKQSIYKT 480
IESKAQECFQ ERSNKVCGNS RVDEGEECDP GIMYLNNDTC CNSDCTLKPG VQCSDRNSPC 540
CKNCQFETAQ KKCQEAINAT CKGVSYCTGN SSECPPPGDA EDDTVCLDLG KCKAGKCIPF 600
CKREQELESC ACVDTDNSCK VCCRNLSGPC VPYVDAEQKN LFLRKGKPCT VGFCDMNGKC 660
EKRVQDVIER FWDFIDQLSI NTFGKFLADN IVGSVLVFSL IFWIPFSILV HCVDKKLDKQ 720
YESLSLFHHS NIEMLSSMDS ASVRIIKPFP APQTPGRLQA LQPAAMMPPV PAAPKLDHQR 780
MDTIQEDPST DSHADDDGFE KDPFPNSSTA AKSFEDLTDH PVTRSEKAAS FKLQRQSRVD 840
SKETEC 846 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:MGI.
 GO:0004222; F:metalloendopeptidase activity; IEA:InterPro.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW. 
Interpro
 IPR001762; Blood-coag_inhib_Disintegrin.
 IPR024079; MetalloPept_cat_dom.
 IPR001590; Peptidase_M12B.
 IPR002870; Peptidase_M12B_N. 
Pfam
 PF00200; Disintegrin
 PF01562; Pep_M12B_propep 
SMART
 SM00050; DISIN 
PROSITE
 PS50215; ADAM_MEPRO
 PS50214; DISINTEGRIN_2 
PRINTS