CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-032437
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 TBC1 domain family, member 2B 
Protein Synonyms/Alias
  
Gene Name
 TBC1D2B 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
43RLCGYLQKLSGKGPLubiquitination[1]
Reference
 [1] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724] 
Functional Description
  
Sequence Annotation
  
Keyword
  
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 965 AA 
Protein Sequence
MPGAGDGVEE SCSGGEGAVP GTGSEAGAVA GREPSRLCGY LQKLSGKGPL RGYRSRWFVF 60
DSRRCYLYYF KSPQDALPLG HLDIADACFS YQGRDEAAEP GADPPTHFQV HSAGAVTVLK 120
APNRELMTYW LQELQQKRWE YCNSLDMMKW DSRTSPTPGD FPKGLVARDT TDIISQHPNP 180
SAEKARTVLA VEAAPGELVG DRAAHQPAPG HPNPINFYSL KQWGNELKNS MSSFRPGRGH 240
SESRRTVFYT NEEWELLDPP PKDLEESLVP EERKKPMPEG SKGVASSGFP FEFGRNPYKG 300
KRPLKDIIGS YKNRHSSSDP LLEGTATSSG SSGGPTKPVP EMQLQIQSQQ EELEQLKKDL 360
SSQKELIRLL QQTVRSSQYD KYFTNPQISQ GVPGDTLELL HQKDEQILGL SGQLERFGLE 420
KESLQQEVRT LKSKVGELNE RLGMLMETIQ AKDEVIIKLS ACEGSVSSPT LGPSSPLAIP 480
ASKDQLELDR LKDSLQGYKS QNKFLNKEIL ELSALRRNAE RRERDLMAKY SSLEAKLCQV 540
ESKYLILLQE MKTPVCSEEQ GPARDVIAQL LEDALQVESQ EQPEQAFVKP HLVSEFDIYG 600
FRTVPDDDEE EKLVAKVRAL DLKTLYLTDN QEVSTGVKWE NYFASTMNRE MACSPELKNL 660
IRAGIPHEHR SKVWKWCVDR HTRKFKDSME PDYFQTLLQK ALEKQNPASK QIELDLLRTL 720
PNNKHYSSPT SEGIQKLRSV LLAFSWRNPD IGYCQGLNRL VAVALLYLDQ EDAFWCLVTI 780
VEVFMPRDYY TKTLLGSQVD QRVFRDLLSE KLPRLHTHFE QYKVDYTLIT FNWFLVVFVD 840
SVVSDILFKI WDSFLYEGPK VIFRFALALF KYKEEEILKL QDSMSIFKYL RYFTRTILDA 900
RKLISISFGD LNPFPLRQIR NRRAYHLEKV RLELTELEAI REDFLRERDT SPDKGELVSD 960
EEEDT 965 
Gene Ontology
 GO:0005622; C:intracellular; IEA:InterPro.
 GO:0005543; F:phospholipid binding; IEA:InterPro.
 GO:0005097; F:Rab GTPase activator activity; IEA:InterPro.
 GO:0032851; P:positive regulation of Rab GTPase activity; IEA:GOC. 
Interpro
 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology.
 IPR000195; Rab-GTPase-TBC_dom. 
Pfam
 PF00169; PH
 PF00566; RabGAP-TBC 
SMART
 SM00233; PH
 SM00164; TBC 
PROSITE
 PS50003; PH_DOMAIN
 PS50086; TBC_RABGAP 
PRINTS