CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-029249
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Eukaryotic translation initiation factor 4G, isoform B 
Protein Synonyms/Alias
  
Gene Name
 eIF4G 
Gene Synonyms/Alias
 CG10811; Dmel_CG10811 
Created Date
 July 27, 2013 
Organism
 Drosophila melanogaster (Fruit fly) 
NCBI Taxa ID
 7227 
Lysine Modification
Position
Peptide
Type
References
1199TVGAKFEKTPVNSKDacetylation[1]
Reference
 [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
 Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
 Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Initiation factor; Protein biosynthesis; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1919 AA 
Protein Sequence
MQQAIPTLPT QSDIDKAMQP HSAQNMILPA NKKTKKYDQQ VPTSKPQSLH QPLQPQHSHP 60
TAQPQFQINK AYNVVSILKA SAQIAQQSPH LTNQQHPPIH HPQQTQQHQQ SYTNVVNRSL 120
SASEPVRAQS SVICNGSSIL TVNSRQLNSG DMNSTAIYNI SSYRKLTGSL DGNVCFLNVQ 180
DIKQNGNISG SVVSNKSIVG VGSEKSSCTG VSINNQIVLP NAQIGTSMGI AGTTTAGTSY 240
MHEKNIVGVS VNCVNTSKKY DFNNSSLLSN NSYPASTAEY VSTGNNNSGN TRSNPQSGGI 300
FRGPPSTPNA PRGASGGATR HVHVQPMYSQ PLHQNMVLQQ YTQYNPRQQT FPASHLQYAP 360
APMPYYQYQY VPTLQQQPPH TRSAVTVNTN VNVGNNLQPV QSGPNGPLPV PGASSSQIQL 420
LTSTVQPGAS TVMGVGGPGS TMGQVGVPPM VGVGVMTTSV QPQPVQVQPA SRRRHQHRLQ 480
IIDPTTKKNI LDDFDKTKSN TDNEFSDQVT STNTPATVLS EGPIRIPQQE SVGLNNLTST 540
SSQGSESRTN APYIPIETTP ISRTDVGPTP IVSAMTDAPS VEILPTPQRG RSKKIPIVSP 600
KNVSESIVAP ITDETDDAGS TPISRATEES MPPNQTHPNL LISDSSKHKQ AVSNSEISKD 660
APTGLKEMHV AELESSVASE NHPAGILDVN VNKSSQSLDF SADPEIDSIG AISPTSPNAV 720
SPILHEVLDN TELSKKLENS TTERFKDSQS VEKPTHQELS LRNATDETEI SAMALQDVNS 780
LDNNQIEKTY PSKPKLNVDV SEDISSRESA IKSTSTKNTG VDVGLQSDSK PETTLNDKQD 840
STDLKVKVSA KISSIINYNE GQWSPNNPSG KKQYDREQLL QLREVKASRI QPEVKNVSIL 900
PQPNLMPSFI RNNNNNKRVQ SMVGIIGNRS NESAGNYIGK QMSMSGVQSG GGRSSMKGMI 960
HVNLSLNQDV KLSENENAWR PRVLNKSDGD SDAKSALEKD ELVRRVRGIL NKLTPERFDT 1020
LVEEIIKLKI DTPDKVDEVI VLVFEKAIDE PNFSVSYARL CQRLAAEVKV IDERMESETK 1080
SNSAHFRNAL LDKTEQEFTQ NVSQSTAKEK KLQPIVDKIK KCTDANEKAE LEAFLEEEER 1140
KIRRRSGGTV RFIGELFKIS MLTGKIIYSC IDTLLNPHSE DMLECLCKLL TTVGAKFEKT 1200
PVNSKDPSRC YSLEKSITRM QAIASKTDKD GARVSSRVRF MLQDVIDLRK NKWQTSRNEA 1260
PKTMGQIEKE AKNEQLSAQY FGTLSSTTPG GSQGGSGKRD DRGNSRYGES RSSSAYGGSH 1320
SQRGDNGNLR HQQQNNVGGN VSGGAGHSNG NNDENTWHVQ TSKGSRSLAV DSNKLEGLSK 1380
LSDQNLETKK MGGLTQFIWI SSDTTRLSSA PTPTPSNPFA VLSSLIDKNS NERDRDRSGP 1440
RNKGSYNKGS MERDRYDRGM HSRTGSSQGS RENSSSRGGQ QGRTLLSSSV QKSTSHSKYT 1500
QQAPPTRHTV KAQSSVGSSN VNTGPLYRGS EQQTSATFSQ TTRSVAPVAV FIEASETDLK 1560
LIKSVVSEIV DLSAASKEVT PGAVSCIKRV PEKLRCSFIY YILTDYLHLA NVGKQYRRYL 1620
SIAVSQLIQQ NYISADHLRL AYNEFTVYAN DLIVDIPELW LYILQFAGPL IVKKILTISD 1680
LWNNNLKENS PSNVAKKFLK TYLIYCTQEV GPNFARNMWI KFNLKWSDFM PESEVADFIK 1740
FNRLEYVENE SKSPVIDHRE TPEKHVKNVI DHIEHLLKEG TTADCIIDYS NGNIMVVDKL 1800
FIRGLTETLS NFSIHYKDNS YKLESETFQK FCIPVLQRYI DSNEDHQLEC LYTLQLLVHG 1860
LEHPRGLLSE LIGELYDAFV IQKESLCKWR DSKDQSAGKG VAVKSLNPFF NSLLNDDAN 1919 
Gene Ontology
 GO:0005829; C:cytosol; ISS:FlyBase.
 GO:0016281; C:eukaryotic translation initiation factor 4F complex; IDA:FlyBase.
 GO:0003677; F:DNA binding; IEA:InterPro.
 GO:0000340; F:RNA 7-methylguanosine cap binding; IDA:FlyBase.
 GO:0003743; F:translation initiation factor activity; ISS:FlyBase.
 GO:0000082; P:G1/S transition of mitotic cell cycle; IMP:FlyBase.
 GO:0007067; P:mitosis; IMP:FlyBase.
 GO:0007095; P:mitotic G2 DNA damage checkpoint; IGI:FlyBase.
 GO:0000022; P:mitotic spindle elongation; IMP:FlyBase.
 GO:0016070; P:RNA metabolic process; IEA:InterPro. 
Interpro
 IPR016024; ARM-type_fold.
 IPR003891; Initiation_fac_eIF4g_MI.
 IPR016021; MIF4-like_typ_1/2/3.
 IPR003890; MIF4G-like_typ-3.
 IPR003307; W2_domain. 
Pfam
 PF02847; MA3
 PF02854; MIF4G 
SMART
 SM00515; eIF5C
 SM00544; MA3
 SM00543; MIF4G 
PROSITE
 PS51366; MI
 PS51363; W2 
PRINTS