CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-007709
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Coatomer subunit delta 
Protein Synonyms/Alias
 Delta-coat protein; Delta-COP 
Gene Name
 RET2 
Gene Synonyms/Alias
 YFR051C 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
14SITTRQGKPLLSRQFubiquitination[1]
53DHTFVEDKHVRYVYRubiquitination[1]
153QEIIERNKEIEATEEacetylation[2]
153QEIIERNKEIEATEEubiquitination[1]
176ARKEHERKHGFMSSNacetylation[2]
348RDKSFQFKTHPNIDKacetylation[2]
Reference
 [1] Global analysis of phosphorylation and ubiquitylation cross-talk in protein degradation.
 Swaney DL, Beltrao P, Starita L, Guo A, Rush J, Fields S, Krogan NJ, Villén J.
 Nat Methods. 2013 Jul;10(7):676-82. [PMID: 23749301]
 [2] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 
Functional Description
 The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non- clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity). 
Sequence Annotation
 DOMAIN 288 546 MHD.
 REGION 190 440 Interaction with DSL1.
 MOD_RES 277 277 Phosphothreonine.  
Keyword
 Complete proteome; Cytoplasm; Cytoplasmic vesicle; Direct protein sequencing; ER-Golgi transport; Golgi apparatus; Membrane; Phosphoprotein; Protein transport; Reference proteome; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 546 AA 
Protein Sequence
MVVLAASITT RQGKPLLSRQ FKDLSKDRVL ELLSNFQNLV SEISSDHTFV EDKHVRYVYR 60
PFDNYYIILI TNRQSNIIKD LATLNLFSQT INSYLSSFQD QEIFHNAFEI LSSFDEIVSM 120
GGYKENLSFT QVQTYLSMES HEERIQEIIE RNKEIEATEE RKRRAKEIAR KEHERKHGFM 180
SSNGDYDGAN RFMGSKDPNV TNAINSYYSH ASPAAQQSYL QSSHAAAAEV APVASPMATS 240
QRAGHSATGG MKLGGGAGRR AGAAPRPSAI SSASSGTPPP PEEDVPENNG ILISIKEVIN 300
AEFSRDGTIH SSELKGVLEL RINDHDLSHS NLKLADSIDV RDKSFQFKTH PNIDKQSFLS 360
TKLISLRDKS KAFPANDQSL GVLRWRKVAP AEDDSLIPLT LTTWVSPSES QQGFDVIIEY 420
ESVLETELAD VIFTIPVFPQ EPVDINTESS TCSDAEVVNM DQEMGTSIKI SKIAANDAGA 480
LAFTIEAPYE DALYPMTVSF QESTRDKLAK SFTGMAIQSV VMANDHDQEL PYDVITSLKS 540
DEYLVQ 546 
Gene Ontology
 GO:0030131; C:clathrin adaptor complex; IEA:InterPro.
 GO:0030126; C:COPI vesicle coat; IMP:SGD.
 GO:0006888; P:ER to Golgi vesicle-mediated transport; IMP:SGD.
 GO:0048313; P:Golgi inheritance; IGI:SGD.
 GO:0051645; P:Golgi localization; IGI:SGD.
 GO:0006886; P:intracellular protein transport; IEA:InterPro.
 GO:0006890; P:retrograde vesicle-mediated transport, Golgi to ER; IMP:SGD. 
Interpro
 IPR022775; AP_mu_sigma_su.
 IPR008968; Clathrin_mu_C.
 IPR027059; Coatomer_dsu.
 IPR011012; Longin-like_dom. 
Pfam
 PF00928; Adap_comp_sub
 PF01217; Clat_adaptor_s 
SMART
  
PROSITE
 PS51072; MHD 
PRINTS