UniProt Accession

 ACOD1_MOUSE; P13516; Q922I6 

Genbank Protein ID

 M21285; M21280; M21281; M21282; M21283; M21284; BC007474; BC055453 

Genbank Nucleotide ID

 AAA40103.1; AAA40103.1; AAA40103.1; AAA40103.1; AAA40103.1; AAA40103.1; AAH07474.1; AAH55453.1 

Protein Name

 Acyl-CoA desaturase 1 

Protein Synonyms/Alias

 Delta(9)-desaturase 1; Delta-9 desaturase 1; Fatty acid desaturase 1; Stearoyl-CoA desaturase 1 

Gene Name

 Scd1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
30	PSGNEREKVKTVPLH	ubiquitination	[1]
32	GNEREKVKTVPLHLE	ubiquitination	[1]
47	EDIRPEMKEDIHDPT	ubiquitination	[1]
64	DEEGPPPKLEYVWRN	ubiquitination	[1]
158	RDHRAHHKFSETHAD	ubiquitination	[1]
195	AVKEKGGKLDMSDLK	acetylation	[2]
195	AVKEKGGKLDMSDLK	ubiquitination	[1]
202	KLDMSDLKAEKLVMF	acetylation	[2]
202	KLDMSDLKAEKLVMF	ubiquitination	[1]
205	MSDLKAEKLVMFQRR	ubiquitination	[1]
334	GLAYDRKKVSKATVL	ubiquitination	[1]
337	YDRKKVSKATVLARI	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 

Functional Description

 Terminal component of the liver microsomal stearyl-CoA desaturase system, that utilizes O(2) and electrons from reduced cytochrome b5 to catalyze the insertion of a double bond into a spectrum of fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA. 

Sequence Annotation

 MOTIF 116 121 Histidine box-1.
 MOTIF 153 157 Histidine box-2.
 MOTIF 294 298 Histidine box-3.  

Keyword

 Complete proteome; Endoplasmic reticulum; Fatty acid biosynthesis; Fatty acid metabolism; Iron; Lipid biosynthesis; Lipid metabolism; Membrane; Oxidoreductase; Reference proteome; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 355 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005506; F:iron ion binding; IEA:InterPro.
 GO:0004768; F:stearoyl-CoA 9-desaturase activity; IEA:EC.
 GO:0050873; P:brown fat cell differentiation; IDA:MGI.
 GO:0034435; P:cholesterol esterification; IMP:MGI.
 GO:0050830; P:defense response to Gram-positive bacterium; IMP:MGI.
 GO:0006633; P:fatty acid biosynthetic process; IMP:MGI.
 GO:0044130; P:negative regulation of growth of symbiont in host; IMP:MGI.
 GO:0010873; P:positive regulation of cholesterol esterification; TAS:BHF-UCL.
 GO:0050872; P:white fat cell differentiation; IDA:MGI. 

Interpro

 IPR005804; Fatty_acid_desaturase-1.
 IPR001522; Fatty_acid_desaturase-1_C.
 IPR015876; Fatty_acid_desaturase-1_core. 

Pfam

 PF00487; FA_desaturase 

SMART

  

PROSITE

 PS00476; FATTY_ACID_DESATUR_1 

PRINTS

 PR00075; FACDDSATRASE.