CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-019513
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 N-terminal EF-hand calcium-binding protein 3 
Protein Synonyms/Alias
 Amyloid beta A4 protein-binding family A member 2-binding protein; Nek2-interacting protein 1; Neuronal calcium-binding protein 3; X11L-binding protein 51 
Gene Name
 NECAB3 
Gene Synonyms/Alias
 APBA2BP; NIP1; SYTIP2; XB51 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
136LEYERASKVDQFVTRubiquitination[1]
365HQQSPGSKAFQRILIubiquitination[1, 2]
Reference
 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094] 
Functional Description
 Inhibits the interaction of APBA2 with beta-amyloid precursor protein (APP), and hence allows formation of beta- amyloid. 
Sequence Annotation
 DOMAIN 36 71 EF-hand.
 DOMAIN 304 366 ABM.  
Keyword
 Alternative splicing; Calcium; Complete proteome; Golgi apparatus; Metal-binding; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 396 AA 
Protein Sequence
MACAGLLTVC LLRPPAPQPQ PQTPRHPQLA PDPGPAGHTL FQDVFRRADK NDDGKLSFEE 60
FQNYFADGVL SLGELQELFS GIDGHLTDNL ETEKLCDYFS EHLGVYRPVL AALESLNRAV 120
LAAMDATKLE YERASKVDQF VTRFLLRETV SQLQALQSSL EGASDTLEAQ AHGWRSDAES 180
VEAQSRLCGS RRAGRRALRS VSRSSTWSPG SSDTGRSSEA EMQWRLQVNR LQELIDQLEC 240
KVRAVGPGPH KGGPSWYPPE PGPCWRPGPH SVPSQAPRLE PLREEDLAKG PDLHILMAQR 300
QVQVAEEGLQ DFHRALRCYV DFTGAQSHCL HVSAQKMLDG ASFTLYEFWQ DEASWRRHQQ 360
SPGSKAFQRI LIDHLRAPDT LTTVFFPASW WIMNNN 396 
Gene Ontology
 GO:0005789; C:endoplasmic reticulum membrane; IDA:UniProtKB.
 GO:0000137; C:Golgi cis cisterna; IDA:UniProtKB.
 GO:0005634; C:nucleus; NAS:UniProtKB.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0019538; P:protein metabolic process; IDA:UniProtKB.
 GO:0009306; P:protein secretion; NAS:UniProtKB.
 GO:0042984; P:regulation of amyloid precursor protein biosynthetic process; IDA:UniProtKB. 
Interpro
 IPR007138; Antibiotic_mOase.
 IPR011008; Dimeric_a/b-barrel.
 IPR011992; EF-hand-like_dom.
 IPR018247; EF_Hand_1_Ca_BS.
 IPR002048; EF_hand_dom. 
Pfam
 PF03992; ABM
 PF13202; EF_hand_3 
SMART
  
PROSITE
 PS00018; EF_HAND_1
 PS50222; EF_HAND_2 
PRINTS